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CD61, also known as GPIIIa, is a 110 kDa glycoprotein that belongs to integrin family of proteins.
Some experts have demonstrated that genetic polymorphisms of platelet membrane glycoproteins (GPI1, GPIba, GPIIIa, and GPIV) may influence the efficacy of aspirin or platelet responsiveness, and genetic polymorphisms of the thromboxane A2 receptor (TBXA2R), platelet-activating factor acetylhydrolase, and coagulation factor XIII were associated with platelet aggregation.
Thrombocytopenia is a common problem in HIV owing to cross-reactivity of antibodies to HIV with glycoprotein GPIIb and/ or GPIIIa on the platelet surface or talin within the platelet cytoskeleton.
El tipo I es la mas comun con menos del 5% GPIIb o GPIIIa, tipo II tiene de 10-20% de la cantidad normal de la glicoproteina y la variante que se caracteriza por valores mayores a 20% pero disfuncionales (1).
GPIIIa (CD61) is an important adhesion protein that is responsible for mediating platelet activation and aggregation (Merten et al.
Molecular Biology schemes: Factor V-Leiden, prothrombin, MTHFR, PAII (SERPINE1), factor XIII (F13A1), GPIIIa (1TGB3), [3Fib (FGB), VKORC1, Factor XII (F12), a1 PI, APOE, APOB, ACE, CETP, TPMT, CYP2C19, CYP2D6, CYP2C8, CYP2C9, UGT1A1 , DPD (DPYD), BCHE, ALDOB, HFE, LCT, NOD2, ATP7B, FSAP (HABP2), ITGA2, KRAS.
A meta-analysis of 31 studies examining 50 polymorphisms in 11 genes showed that only GPIIIa gene polymorphism was associated with aspirin resistance (22).
The results of laboratory tests for her parents were all normal, including the results of a flow cytometric analysis of GPIIb and GPIIIa.
Statins, for instance, could reduce the expression of GPIIIa antigen, P-selectin and TF on PMPs in patients with diabetes, dyslipidemia or peripheral arterial occlusive disease, [sup],, while statins exert controversial effects on EMP levels.
24) The other class of antiplatelet agents is represented by abciximab, a biologic agent consisting of human-murine chimeric Fab fragments specific for platelet GPIIIa.
Higher prevalence of GPIIIa PlA2 polymorphism in siblings of patients with premature coronary heart disease.
A2] allelic form, which arises through a single T-to-C nucleotide substitution at nucleotide 1565 of the GPIIIa gene and the substitution of proline for leucine at position 33, may produce platelets with a lower activation threshold than [Pl.
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