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Thrombocytopenia is a common problem in HIV owing to cross-reactivity of antibodies to HIV with glycoprotein GPIIb and/ or GPIIIa on the platelet surface or talin within the platelet cytoskeleton.
GPIIIa (CD61) is an important adhesion protein that is responsible for mediating platelet activation and aggregation (Merten et al.
Molecular Biology schemes: Factor V-Leiden, prothrombin, MTHFR, PAII (SERPINE1), factor XIII (F13A1), GPIIIa (1TGB3), [3Fib (FGB), VKORC1, Factor XII (F12), a1 PI, APOE, APOB, ACE, CETP, TPMT, CYP2C19, CYP2D6, CYP2C8, CYP2C9, UGT1A1 , DPD (DPYD), BCHE, ALDOB, HFE, LCT, NOD2, ATP7B, FSAP (HABP2), ITGA2, KRAS.
A meta-analysis of 31 studies examining 50 polymorphisms in 11 genes showed that only GPIIIa gene polymorphism was associated with aspirin resistance (22).
The results of laboratory tests for her parents were all normal, including the results of a flow cytometric analysis of GPIIb and GPIIIa.
New Invader(R) DNA reagents are now available for the following analytes: * ApoE (C112R) * ApoE (R158C) * GPIIIa (PLA1/A2) * GPIa (C807T)
24) The other class of antiplatelet agents is represented by abciximab, a biologic agent consisting of human-murine chimeric Fab fragments specific for platelet GPIIIa.
Higher prevalence of GPIIIa PlA2 polymorphism in siblings of patients with premature coronary heart disease.
A2] allelic form, which arises through a single T-to-C nucleotide substitution at nucleotide 1565 of the GPIIIa gene and the substitution of proline for leucine at position 33, may produce platelets with a lower activation threshold than [Pl.
The FVL, FII G20210A, MTHFR C677T, GPIa C807T, ACE D/I, and GPIIIa T1565C genotype frequencies and allele frequencies were initially analyzed independently for changes in frequency among the 17-39 years, 40-59 years, and 60-85 years groups.
Glycoprotein IIb-IIIa, particularly the GPIIIa subunit, has been found to be highly polymorphic.
A] polymorphism of the GPIIIa subunit of the fibrinogen receptor, and (2) it could not be mediated by a classic genomic effect of the estrogen receptor, as platelets are anucleated fragments derived from megakaryocytes.
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