ITGA2

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ITGA2

A gene on chromosome 5q11.2 that encodes an integrin alpha chain protein which, like all integrins, forms a heterodimer with a beta chain, thereby participating in an array of cell-cell and cell-matrix interactions, playing a major role in cell migration, organ and tissue development and differentiation. Alpha-2 beta-1 heterodimers serve as receptors for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin, and is responsible for adhesion of platelets and other cells to the extracellular matrix, modulation of collagen and collagenase gene expression and organisation of newly synthesised extracellular matrix.
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References in periodicals archive ?
The GPIA was created by the Paris Chamber of Commerce and Industry 15 years ago to highlight Greater Paris as the business capital of Europe.
The GPIA argued that subsequent use, process, and other patents extended the patent terms for many brand-name drugs so that these drugs essentially maintained their monopoly markets.
The involvement of the GPIA created both a stumbling block for the proponents of patent-term extension and a renewed interest in changing the regulatory process for generics.
Recognizing such an opportunity, Hatch initiated a series of private negotiations with Waxman and members from the PMA and the GPIA to develop a bill to accommodate both brand-names and generics.
42) The bill was supported by the board of the PMA and the GPIA.
GPIA, "Fact Sheet on Patent Extension," Hearings before the Subcommittee on Investigations and Oversight of the Committee on Science and Technology, U.