ITGA2

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ITGA2

A gene on chromosome 5q11.2 that encodes an integrin alpha chain protein which, like all integrins, forms a heterodimer with a beta chain, thereby participating in an array of cell-cell and cell-matrix interactions, playing a major role in cell migration, organ and tissue development and differentiation. Alpha-2 beta-1 heterodimers serve as receptors for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin, and is responsible for adhesion of platelets and other cells to the extracellular matrix, modulation of collagen and collagenase gene expression and organisation of newly synthesised extracellular matrix.
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The GPIA was created by the Paris Chamber of Commerce and Industry 15 years ago to highlight Greater Paris as the business capital of Europe.
The GPIA argued that subsequent use, process, and other patents extended the patent terms for many brand-name drugs so that these drugs essentially maintained their monopoly markets.
The involvement of the GPIA created both a stumbling block for the proponents of patent-term extension and a renewed interest in changing the regulatory process for generics.
NAPM's board did not approve the governance model proposed by GPIA and NPA, which allocated board seats to companies based on their size.
We wish our colleagues in GPIA and NPA well in their unification efforts, and we will strive to work hand-in-hand with their new organization in serving the needs of the industry and the American public.
Although the GPIA and other industry groups succeeded in fighting off that measure, in opposing changes to the Food, Drug and Cosmetic Act and in garnering more funding for the Food and Drug Administration's (FDA's) office of generic drugs (OGD), the battle continues in several other areas.
The inappropriate use of the citizen petition process is another issue that GPIA and others in the industry continue to actively address.
PhRMA says the lawsuit filed by the GPIA and the National Pharmaceutical Alliance (NPA) in an attempt to block further implementation of the provision is nothing more than an attempt to hurt sick children.
We will continue to explore creative approaches to affect the rapidly changing health care industry," says GPIA vice president for government affairs H.
Cohen said that groups like the GPIA should consider linking up with trade associations representing the managed care industry, suggesting such a course would be less expensive and not as time-consuming as working with individual managed care plans.
Suppliers fear that without sufficient resources in that department, review times for abbreviated new drug applications will slow down - a drawback that GPIA chairman Marvin Sampson recently noted not only will hurt the industry but deny patients access to less expensive, therapeutically equivalent generic medications.
While the addition of generics companies to the list of those paying user fees has been rejected by the GPIA, another trade group representing generic drug makers, as well as by most lawmakers, there is some concern in Congress that the plan may be the only way to level the playing field between branded and generic pharmaceutical companies.