GPER


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GPER

A gene on chromosome 7p22.3 that encodes a G protein-coupled receptor that binds oestrogen and is widely distributed in neural, breast cancer, placental, heart, ovarian, prostate, hepatic, vascular epithelial and lymphoid tissue. It plays a role in rapid nongenomic signalling events seen after oestrogen stimulation of cells and tissues.
References in periodicals archive ?
In the present study, we observed that atrazine exerted estrogen-like activity in ovarian and breast cancer cells and in CAFs through GPER, which mediated estrogen signals, as reported in previous studies (reviewed by Prossnitz and Barton 2014).
Furthermore, our data show that GPER and ER[alpha], along with the EGFR/MAPK pathway, contribute to the biological responses to atrazine in diverse cancer cells.
Results of the present study corroborate our previous data regarding the physical interaction between GPER and ER[alpha] and the biological responses triggered by the functional crosstalk of these receptors (Vivacqua et al.
In this study, we demonstrate that BPA exerts a stimulatory action through GPER in breast cancer cells and CAFs.
The short hair-pin (sh) RNA constructs to knock down the expression of GPER and CTGF and the unrelated shRNA control construct have been described previously (Pandey et al.
Using SKBR3 cells and CAFs, which both express GPER and lack ERs [see Supplemental Material, Figure Si (http://dx.
In the present study the ER[alpha]-selective ligand PPT caused both ERK phosphorylation and proliferation, consistent with that hypothesis, whereas selective GPER liganding mostly inhibited both processes at expected physiologic concentrations.
We have examined only limited cases, where ER[alpha] and perhaps GPER are involved in causing some kinase activations/deactivations.
Bateman, of the law firm of Nobbs, Woods and Clark, the attorney for Exxadon and current board member, stated at the annual shareholders meeting that the allegations of GPERS are "totally without grounds or merit" as was similarly stated in Exxadon's news release of July 3, 1996.
Allen's attorney said his client merely wants EWMC to honor its contract with GPERS so that, subject to the tire reduction system being completed, sales in California and elsewhere can proceed and she can comfortably increase her investment in what she hopes, based upon EWMC's promises, will be a profitable and environmentally beneficial technology.
In an effort to induce GPERS to enter into the License Agreement EWMC invited Moore (GPERS President James E.
One section of the arbitration claim filed by GPERS states: