GPER


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GPER

A gene on chromosome 7p22.3 that encodes a G protein-coupled receptor that binds oestrogen and is widely distributed in neural, breast cancer, placental, heart, ovarian, prostate, hepatic, vascular epithelial and lymphoid tissue. It plays a role in rapid nongenomic signalling events seen after oestrogen stimulation of cells and tissues.
References in periodicals archive ?
Furthermore, our data show that GPER and ER[alpha], along with the EGFR/MAPK pathway, contribute to the biological responses to atrazine in diverse cancer cells.
Results of the present study corroborate our previous data regarding the physical interaction between GPER and ER[alpha] and the biological responses triggered by the functional crosstalk of these receptors (Vivacqua et al.
Here, we have provided novel insights regarding the potential role of GPER in mediating the action of atrazine, not only in estrogen-sensitive tumors but also in CAFs.
Two novel GPER agonists induce gene expression changes and growth effects in cancer cells.
Using SKBR3 cells and CAFs, which both express GPER and lack ERs [see Supplemental Material, Figure Si (http://dx.
BPA stimulates the expression of GPER target genes.
The proliferative effects observed in both SKBR3 cells and CAFs after 5-day treatment with BPA were cancelled when GPER expression was silenced by shGPER (Figure 5A, B).
Bateman, of the law firm of Nobbs, Woods and Clark, the attorney for Exxadon and current board member, stated at the annual shareholders meeting that the allegations of GPERS are "totally without grounds or merit" as was similarly stated in Exxadon's news release of July 3, 1996.
Allen's attorney said his client merely wants EWMC to honor its contract with GPERS so that, subject to the tire reduction system being completed, sales in California and elsewhere can proceed and she can comfortably increase her investment in what she hopes, based upon EWMC's promises, will be a profitable and environmentally beneficial technology.
One section of the arbitration claim filed by GPERS states:
5 million system to protect taxpayers' monies, GPERS would be guilty of grand theft by false pretense, which is a criminal offense.
GPERS feels that serious harm has already been caused to GPERS and its shareholders by the unprincipled actions of EWMC.