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Various genes like glypican 6 (GPC6) gene, GPC5 gene, and gga-mir-17-92 cluster, Popeye domain-containing protein 1, Opioid-binding protein/cell adhesion molecule-like, Cbfa2t2 were found to be associated with body weight at different growth stages.
Based on a comparison of the two groups, a genetic variation at the location of the GPC5 gene - a genetic sequence called rs3864180 - was found to be associated with a reduced risk of sudden cardiac arrest.
Researchers found in laboratory studies that this allele leads to greatly reduced GPC5 expression, compared to normal lung tissue.
What's more, our findings suggest GPC5 may be a critical gene in lung cancer development and genetic variations of this gene may significantly contribute to increased risk of lung cancer," she says.
Little is known about the GPC5 gene, except that it can be over-expressed in multiple sclerosis, and that alterations in the genome where GPC5 is located are a common event in a wide variety of human tumors.
Both of these hits were adjacent to each other on the same gene, which the researchers then identified as a variant of GPC5.
We had to understand whether these hits really represented the functional aspect of the gene, so we tested expression level of GPC5 and found it was significantly reduced," Dr.
The research team, co-led by scientists at the Mayo Clinic campus in Minnesota, Harvard University, University of California at Los Angeles (UCLA), and MD Anderson Cancer Center, found that about 30 percent of patients who never smoked and who developed lung cancer had the same uncommon variant, or allele, residing in a gene known as GPC5.
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