GP5


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GP5

A gene on chromosome 3q29 that encodes a protein which is part of the Ib-V-IX system of platelet surface membrane glycoproteins, which comprise the von Willebrand factor receptor and mediate adhesion of platelets to injured vascular surfaces with circulation, a critical event in haemostasis.
References in periodicals archive ?
Identification of neutralizing and nonneutralizing epitopes in the porcine reproductive and respiratory syndrome virus GP5 ectodomain.
The primary GP5 neutralization epitope of North American isolates of porcine reproductive and respiratory syndrome virus.
Full-length genomic sequencing of 1 of the isolates (HUN4 strain) showed extensive amino acid (aa) mutations in GP5 protein and 2 deletions in Nsp2, 1 aa deletion at 482, and 29 aa deletions at 533-561, compared with the previous Chinese isolates CH-la and B J-4.
Furthermore, viruses reisolated from the dead pigs showed an identical homology with the inoculated PRRSV in genes coding for GP5 and partial Nsp2 (2,535-3,307 nt).
The primary structural proteins of arteriviruses are the nucleocapsid (N) protein, the integral membrane/matrix (M) protein, and the primary envelope glycoprotein, GP5 (10-12).
The single neutralization epitope located in the middle of GP5 ectodomain (Figure 1) is flanked in the common LDV isolates, represented by LDV-P (10), by two N-glycans that impair the immunogenicity of the epitope and render the viruses completely resistant to in vivo Ab neutralization (18,19).