GP5


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GP5

A gene on chromosome 3q29 that encodes a protein which is part of the Ib-V-IX system of platelet surface membrane glycoproteins, which comprise the von Willebrand factor receptor and mediate adhesion of platelets to injured vascular surfaces with circulation, a critical event in haemostasis.
References in periodicals archive ?
The primary GP5 neutralization epitope of North American isolates of porcine reproductive and respiratory syndrome virus.
Furthermore, viruses reisolated from the dead pigs showed an identical homology with the inoculated PRRSV in genes coding for GP5 and partial Nsp2 (2,535-3,307 nt).
The single neutralization epitope located in the middle of GP5 ectodomain (Figure 1) is flanked in the common LDV isolates, represented by LDV-P (10), by two N-glycans that impair the immunogenicity of the epitope and render the viruses completely resistant to in vivo Ab neutralization (18,19).
For example, the GP5 ectodomains of LDV, PRRSV VR-2332, and PRRSV Lelystad virus are collinear and contain a segment with approximately 70% amino acid identity (Figure 1).