GNB3


Also found in: Acronyms.

GNB3

A gene on chromosome 12p13 that encodes a beta subunit of a heterotrimeric guanine nucleotide-binding protein (G protein), which regulates signal transduction between receptors and effectors.

Molecular pathology
A single-nucleotide polymorphism in GNB3 is associated with essential hypertension and obesity.
References in periodicals archive ?
No difference in absolute changes in SBP, DPB or MAP among GNB3 C825T genotypes was observed after either telmisartan or amlodipine therapy.
In this study, we investigated the effect of GNB3 C825T polymorphism on antihypertensive effects of telmisartan and amlodipine in Chinese EH patients.
GNB3 C825T polymorphism is a splice variant that results in gain-of-function.
What's more, the effects of GNB3 C825T polymorphism are likely to be tissue and/or stimuli specific.
Several studies have observed an association of the GNB3 825T polymorphism with obesity in the different population though controversial reports are also available.
No significant association between GNB3 C825T polymorphism and telmisartan therapy was found when an absolute decrease in BP levels was analyzed.
Allele and genotype frequencies of the GNB3 gene Control Hypertension GNB3 genotypes groups group p (n=82) (n=209) CC, n (%) 27 (32.
All patients were genotyped for GNB3 C825T polymorphism and next analyzed in regard to typical vasovagal history.
The frequency of GNB3 825C allele was significantly higher in patients with typical vasovagal history than in patients with non-typical history and the manifestation of GNB3 825T allele prevailed in patients with non-typical history (p < 0.
In vasovagal patients, we found strong association between the GNB3 C825 allele and typical vasovagal history.
In conclusion, we have characterized vasovagal patients in regard to GNB3 C825T polymorphism and typical history.
The predisposition to vasovagal syncope seems to be not associated with the GNB3 825T allele.