CSF2

(redirected from GMCSF)
Also found in: Acronyms.

CSF2

A gene on chromosome 5q23-q31 that encodes colony stimulating factor 2 (granulocyte-macrophage), a cytokine that controls the production, differentiation and function of granulocytes and macrophages.

Molecular pathology
CSF2 is localised to a cluster of related genes at chromosome 5q31, a region associated with deletions in the 5q- syndrome and acute myelogenous leukaemia.
References in periodicals archive ?
She was managed at home as a participant in a study of the therapeutic effect of GMCSF in PAP.
At this time, her doctors contacted doctors and researchers in Australia, who were in charge of a study of the treatment of PAP with human recombinant bacterially synthesized GMCSF.
began receiving daily subcutaneous injections of GMCSF during a readmission to the hospital in August 1997.
By the end of June, all treatment orders had been discontinued except her injections of GMCSF, which were decreased from daily to 3 times per week.
The adverse effects profile of GMCSF, which includes fever, chills, myalgia, flu-like symptoms, nausea, and headache, limit its use (Coyle, 1997).
INF-[alpha]being a potent paracrine molecule can induce other proinflammatory cytokines like IL-1[beta] and GMCSF and hence plays a pivotal role in the pathogenesis of RA and other inflammatory conditions (Feldmann et al.
pyogenes induced substantial amounts of the pro-inflammatory cytokines IL-6, 1L-8 (CXCL8), MCP-1, GMCSF, GRO[alpha], and smaller but significant amounts of IL-4 and MIP-1[alpha].
The migrated lymphocytes, of which the functions are modulated by the active ingredients of TJ-48 in Peyer's patches, are postulated to regulate the systemic and mucosal immune system through cytokines such as IL-6 and GMCSF.