GM2gangliosidosis

GM2gan·gli·o·si·do·sis

(gang'glē-ō-si-dō'sis)
One of the hereditary metabolic disorders; several forms exist, including Tay-Sachs disease, Sandhoff disease, AV variant and adult onset; characterized by accumulation of a specific metabolite, GM2 ganglioside, due to deficiency of hexosaminidase A or B, or GM2 activator factor.