1] It was hypothesised that oxidation rates higher than 1 g/min were achieved by overcoming a limitation of a single carbohydrate at the intestinal absorption sites (SGLT-1) [6,7] by utilising alternative carbohydrate transporters located in the intestine, such as GLUT5 for fructose.
The increase in oxidation rates in a mixed carbohydrate drink is hypothesised to be as a result of the increased uptake of mixed carbohydrates by GLUT4 and GLUT5 transporters respectively in the brush border of the gut.
O aumento da glicemia, nesta dieta, pode ser explicado devido ao fato de que apos o excesso de ingestaode frutose nao ocorre um aumento nosniveis de insulina, pois o pancreas nao contem GLUT5 transportadores de frutose, o que limita a absorcao defrutose no pancreas (Tran, Yuen, McNeill, 2009).
Three major isoforms of GLUTs are considered important for glucose delivery to brain cells: GLUT1 is the primary glucose transporter in the blood-brain barrier, choroid plexus, ependyma, and glial cells and is not sensitive to insulin; GLUT3 is the predominant glucose transporter in neurons; GLUT5 is highly expressed in microglia .
Finally, maximally increased GLUT5 expression at the peri-infarct areas has been reported in a rat MCAO model 5 days after stroke that remained elevated until 15 days after the insult , suggesting that GLUT5 activation is consistent with neuroinflammation in response to neuronal necrosis .