SLC2A5

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SLC2A5

A gene on chromosome 1p36.2 that encodes a cytochalasin B-sensitive carrier, which is primarily a fructose transporter.
References in periodicals archive ?
1] It was hypothesised that oxidation rates higher than 1 g/min were achieved by overcoming a limitation of a single carbohydrate at the intestinal absorption sites (SGLT-1) [6,7] by utilising alternative carbohydrate transporters located in the intestine, such as GLUT5 for fructose.
The increase in oxidation rates in a mixed carbohydrate drink is hypothesised to be as a result of the increased uptake of mixed carbohydrates by GLUT4 and GLUT5 transporters respectively in the brush border of the gut.
Gene array studies in hypothyroid patient's skeletal muscle have shown a classical effect on sugar transporter expression by down-regulating the GLUT5 in hypothyroidism.
This mechanism is explained by the different membrane transport, as facilitated passive transport independent of sodium via GLUT5 for fructose and facilitated diffusion via SGLT1 for glucose (33).
O aumento da glicemia, nesta dieta, pode ser explicado devido ao fato de que apos o excesso de ingestaode frutose nao ocorre um aumento nosniveis de insulina, pois o pancreas nao contem GLUT5 transportadores de frutose, o que limita a absorcao defrutose no pancreas (Tran, Yuen, McNeill, 2009).
Three major isoforms of GLUTs are considered important for glucose delivery to brain cells: GLUT1 is the primary glucose transporter in the blood-brain barrier, choroid plexus, ependyma, and glial cells and is not sensitive to insulin; GLUT3 is the predominant glucose transporter in neurons; GLUT5 is highly expressed in microglia [47].
Finally, maximally increased GLUT5 expression at the peri-infarct areas has been reported in a rat MCAO model 5 days after stroke that remained elevated until 15 days after the insult [68], suggesting that GLUT5 activation is consistent with neuroinflammation in response to neuronal necrosis [47].
The regulation of GLUT5 and GLUT2 activity in the adaptation of intestinal brushborder fructose transport in diabetes.
Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP signaling pathway and PABP-interacting protein (Paip) 2.
Presence and differential expression of SGLT1, GLUT1, GLUT2, GLUT3 and GLUT5 hexose-transporter mRNAs in Caco-2 cell clones in relation to cell growth and glucose consumption.
It has been well reviewed that the primary glucose transporters in small intestine were SGLT1, GLUT2 and GLUT5, and SGLT2 in kidney (Zhao and Keating, 2007).
Being a facilitated transporter, GLUT5 will transport fructose down a concentration gradient.