SLC2A4

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SLC2A4

A gene on chromosome 17p13 that encodes insulin-responsive glucose transporter type 4, a plasma membrane that mediates facilitated glucose transport.

Molecular pathology
SLC2A4 mutations are associated with type-2 (non-insulin-dependent) diabetes.
References in periodicals archive ?
Without effective GLUT4 transporters, sugar levels in the blood steadily rise, eventually producing damage to tissues through the chemical reaction known as glycation, in which glucose molecules bind to vital proteins, deleteriously altering both their structure and function.
Em consequencia, o TNF-alfa promove downregulatation dos receptores de IR, e, em associacao com a fosforilacao via serina quinase, atenua intensamente a translocacao do GLUT4 e o transporte de glicose (Ozes e colaboradores, 2001; Kershaw e colaboradores, 2004; Curat e colaboradores, 2004; Fantuzzi, 2004; Leite e colaboradores, Costa e colaboradores, 2006; Almanza-Perez e colaboradores, 2008; Speretta e colaboradores, 2014; Pinto, 2014).
Glucose uptake in cells is regulated by glucose transporters, GLUTI and GLUT4 (Scheepers et al, 2004).
A proteina transportadora transferrina se liga com a cromodulina e pelas vesiculas intracelulares se transloca ate outra proteina, a GLUT4, que entao age com uma maior sinalizacao para captar glicose do meio externo para ser metabolizada internamente (Gomes, Rogero e Tirapegui, 2005).
N-glycosylation is critical for the stability and intracellular trafficking of glucose transporter GLUT4.
This affects the signaling molecule Akt that activates GLUT4 and GLUT4 is then translocated to the membrane and imports glucose into the cell [67].
Essas proteinas sao alocadas dos compartimentos intracelulares como exemplo o GLUT4.
reported that Ang II inhibited insulin-mediated GLUT4 translocation in rat skeletal muscle cells through at least two pathways: (1) the transient activation of ERK1/2 which inhibits IRS1/2 and (2) direct inhibitory nitration of AKT [28].
Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes.
The membrane was incubated with the appropriate primary detection antibodies [affinity-purified rabbit polyclonal antibody to Sir2 (1:1,000 dilution; #07131; Upstate Biotechnology, Lake Placid, NY, USA), PGC-1[alpha] (1:500 dilution; AB3242; Chemicon International, Temecula, CA, USA), or GLUT4 (1:8,000 dilution; AB1346; Chemicon International) or a mouse monoclonal antibody to cytochrome C (1:200 dilution; ANN0012, clone 7H8.
muricata contenidas en capsulas de suplemento nutricional, se demostro que la guanabana inhibe el metabolismo celular e induce necrosis en implantes de celulas de cancer pancreatico, ya que subregulo la expresion de indicadores de hipoxia y glicolisis celular HIF-1[alfa], NF-[kappa]B, GLUT1, GLUT4, HKII, LDHA [18].
Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin.