SLC2A4

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SLC2A4

A gene on chromosome 17p13 that encodes insulin-responsive glucose transporter type 4, a plasma membrane that mediates facilitated glucose transport.

Molecular pathology
SLC2A4 mutations are associated with type-2 (non-insulin-dependent) diabetes.
References in periodicals archive ?
But the molecular evidence showing the functional involvement of stevioside in activating GLUT4 molecules and the subsequent glucose uptake have not been investigated so far effectively.
To the scientists' surprise, although this protein is foreign to the fruit flies, their cells moved GLUT4 to the cell membrane exactly as human cells do in response to insulin.
Primers were designed specifically for GLUT4 and IR by using Primers 5.
If curcumin inhibited glucose transport by interfering with the insulin signaling cascade or by preventing translocation of GLUT4 to the cell surface, then it would be expected that preincubation with curcumin would be required for maximal effect.
Whereas, GLUT4 and other specific adipocyte genes are ameliorated by thiazolidinedione treatment (Diaz-Delfin et al.
Finally, we observed an increase in mRNA levels of GLUT4 in WAT of BPA-exposed females, in agreement with the in vitro--enhanced glucose uptake due to an increased amount of GLUT4 protein, which was observed in 3T3-F442A adipocytes treated with BPA (Sakurai et al.
Protease and phosphatase inhibitor tablets were purchased from Roche (South San Francisco, CA, USA), while Cell Signalling Technology (Beverly, MA, USA) supplied primary antibodies AMPK, p-AMPK (Thr172), AKT, p-AKT (Ser473), PKC [beta], p-PKC [beta] (Ser 643/676) and GLUT4.
In addition, mRNA of ACC, ACL and GLUT4 gene were highly expressed in 29 mo compared with 25 mo and 27 mo (p<0.
In addition to phosphorylated PKB/Akt (p-PKB/Akt), phosphorylated PKC[lambda] (p-PKC[lambda]), and PKC[zeta] (p-PKC[zeta]) are thought to participate in the stimulation of GLUT4 translocation in response to insulin signaling (Elmendorf and Pessin 1999; Ruderman et al.
Both the GLUT4 in skeletal muscle and GLUT2 in liver are the insulin sensitive glucose transporters (Gould and Bell 1990).
PPAR-[gamma]2 is known as a master regulator of adipogenesis because of its ability to transactivate adipogenic target genes such as aP2, GLUT4, fatty acid synthase, LPL, acetyl-CoA carboxylase, and steroyl-CoA desaturase (van Bilsen et al.
TNF-[alpha] is produced by adipocytes also in response to obesity, causing increased expression of the transcription factor NF[kappa]B, and leading eventually to down-regulation of the insulin receptor and the major insulin-responsive glucose transporter GLUT4 (Halle et al.