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They found that GLUT3 levels were lower in brains with Alzheimers pathology compared to normal brains, and that these levels were also connected to the severity of tangles and plaques.
Curcumin has hypoglycaemic and insulin sensitizing effects; in fact it can lower plasmatic glycaemia, reducing hepatic glucose production and inflammation-induced hyperglycaemia, stimulating glucose uptake by the up-regulation of GLUT4, GLUT2 and genes GLUT3 expressions and the activation of AMP kinase, promoting the activity of PPAR ligand, stimulating insulin secretion from pancreatic tissues, improving the functionality of pancreatic cells and reducing insulin resistance (Panahi et al.
Not only does hyperglycaemia enhance urinary losses of vitamin C [11] but, owing to the structural similarity between glucose and dehydroascorbic acid--one of the forms of vitamin C--glucose competitively inhibits the uptake of dehydroascorbic acid by the endothelial common glucose transporters, GLUT1 and GLUT3.
Quantitative expression and immunohistochemical detection of glucose transporters, GLUT1 and GLUT3 in rabbit placenta during successful pregnancy.
Tsakiridis, "Expression of the glucose transporters GLUT1, GLUT3, GLUT4 and GLUT12 in human cancer cells," BMC Proceedings, vol.
Physical influence on spermatozoa, for example through freezing process could lead to the relocation of several proteins as proteins GLUT3 [23].
The focus was on the glucose transporter known as GLUT3, the concentrations of which Onodera and Bissell showed are 400 times greater in malignant than in non-malignant breast cells.
Three major isoforms of GLUTs are considered important for glucose delivery to brain cells: GLUT1 is the primary glucose transporter in the blood-brain barrier, choroid plexus, ependyma, and glial cells and is not sensitive to insulin; GLUT3 is the predominant glucose transporter in neurons; GLUT5 is highly expressed in microglia [47].
Esta capacidade corresponde a predominancia, naqueles tecidos, de transportadores de glicose como GLUT1 (transportador presente em varios tecidos) e o GLUT3 (presente no cerebro) ou o GLUT2 (presente no figado), que respectivamente, apresentam atividades na membrana plasmatica reconhecidamente independente das concentracoes de insulina (Shils e colaboradores, 2003).