GLUL


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GLUL

An intronless gene on chromosome 1q31 that encodes a glutamine synthetase, which catalyses the synthesis of glutamine from glutamate and ammonia. Glutamine is a key source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signalling. GLUL is expressed during early foetal stages, and plays an important role in controlling pH by removing ammonia from circulation.

Molecular pathology
GLUL mutations are associated with congenital glutamine deficiency.
References in periodicals archive ?
A genetic variant in the region of the GLUL gene was identified that is associated with an increased risk of CHD in type 2 diabetics.
The genetic variant may affect CHD risk by reducing the expression of the GLUL gene which is involved in glutamine/glutamic acid metabolism.
Additionally, these neurons were found to secrete favorable neurotrophic factors such as GDNF, BDNF, IGF-1, and astrocytes markers such as S-100-b, GLUL, and GFAP.