GLUD1


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GLUD1

A gene on chromosome 10q23.3 that encodes glutamate dehydrogenase 1, a mitochondrial matrix enzyme which catalyses the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. It plays a key role in regulating amino acid-induced insulin secretion. GLUD1 is allosterically activated by ADP and inhibited by GTP and ATP; it may be involved in learning and memory by increasing the turnover of the neurotransmitter glutamate.

Molecular pathology
Missense mutations of GLUD1 cause hyperinsulinemic hypoglycaemia type 6.
References in periodicals archive ?
The 3 key biomarkers identified as key hubs in the resulting network biology nodes were SPTAN1, CORO1A, and GLUD1.
2] Human genes: ABCC8, ATP-binding cassette subfamily C, member 8; KCNJ11, potassium inwardly rectifying channel, subfamily J, member 11; GCK, glucokinase; GLUD1, glutamate dehydrogenase 1; HADH, hydroxyacyl-Coenzyme A dehydrogenase; SLC16A1, solute carrier family 16, member 1 (monocarboxylic acid transporter 1).