GLUD1

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GLUD1

A gene on chromosome 10q23.3 that encodes glutamate dehydrogenase 1, a mitochondrial matrix enzyme which catalyses the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. It plays a key role in regulating amino acid-induced insulin secretion. GLUD1 is allosterically activated by ADP and inhibited by GTP and ATP; it may be involved in learning and memory by increasing the turnover of the neurotransmitter glutamate.

Molecular pathology
Missense mutations of GLUD1 cause hyperinsulinemic hypoglycaemia type 6.
References in periodicals archive ?
Myiophobus phoenicomitra: The following loci were fixed for the same allele in all taxa: ADA, AK, CK, EAP, FUM, GDA, GLUD, GOT1, GOT2, [Alpha]GPD, GPT, ICD1, ICD2, LDH, MDH1, MDH2, MET, ME2, MPI, PGM1, PGM2, PK, SOD1, SOD2, SORDH, UNK.
sulphureipygius: The following loci were fixed for the same allele in all taxa: CK, EAP, GDA, GLUD, GOT1, GOT2, [Alpha]GPD, GPI, ICD2, LDH, MDH1, MDH2, MET, ME2, MPI, NADPH, PEP-LA, PK, SOD1, SOD2.
Tityra semifasciata: The following loci were fixed for the same allele in all ingroup taxa: ACON2, ADA, AK, CK, EAP, ES-MA, FUM, GDA, GLUD, GOT1, [Alpha]GPD, GSR, ICD1, ICD2, LDH, MDH1, MDH2, ME1, ME2, MPI, NP, PEP-LGG, PEP-VL, PGM2, PK, SOD1.
Chloropipo holochlora: The following loci were fixed for the same allele in all taxa: CK, EAP, ES-MA, FUM, GLUD, GOT2, GPI, ICD1, LDH, MDH1, MDH2, ME1, ME2, NADPH, PEP-LA2, PGD, PGM1, PK, SOD1, SOD2, UNK.
Iuscinia: The following loci were fixed for the same allele in all ingroup taxa: ADA, EAP, FUM, GDA, GLUD, GOT1, GOT2, GSR, ICD2, LDH, MDH1, MDH2, ME1, MPI, NADPH, PGD, PGM2, PK, SOD1, SOD2, SORDH, UNK.
phaeocephalus: The following loci were fixed for the same allele in all ingroup taxa: ADA, AK, CK, EAP, ES-NP2, ES-NP3, FUM, GLUD, GOT1, GOT2, [Alpha]GPD, GSR, ICD2, MDH1, MDH2, ME1, ME2, MPI, PEP-LA, PEP-LGG, PGD, PGM1, PK, SOD1, SOD2, SORDH, UNK.
Microbates cinereiventris: The following loci were fixed for the same allele in all taxa: ADA, CK, EAP, ES-MA, GDA, GLUD GOT I.
assimilis: The following loci were fixed for the same allele in all ingroup taxa: ACON1, ACON2, EAP, ES-MA, FUM, GDA, GLUD, GOT1, GOT2, [Alpha]GPD, GPI, ICD1, ICD2, MDH1, MDH2, ME1, ME2, PEP-LA2, PEP-LGG2, PGM2, PK, SOD1, SOD2.
Chlorophanes spiza: The following loci were fixed for the same allele in all taxa: AK, CK, EAP, GDA, GLUD, GOT1, GOT2, [Alpha]GPD, ICD2, LDH, MDH1, MDH2, ME1, ME2, MPI, PEP-LA1, PEP LGG2, PGD, PGM1, PGM2, PK, SOD1, SORDH.