SLC1A2

(redirected from GLT1)

SLC1A2

A gene on chromosome 11p13-p12 that encodes solute carrier family 1 member 2, a high-affinity glutamate transporter that plays a key role in transporting glutamate across plasma membranes. In the brain, these transporters clear the excitatory neurotransmitter glutamate from the extracellular space at synapses in the CNS and maintain extracellular glutamate concentrations below neurotoxic levels.

Molecular biology
SLC1A2 mutations are associated with amyotrophic lateral sclerosis.
References in periodicals archive ?
The study showed that when rats taking large doses of cocaine are withdrawn from the drug, the production of GLT1 in the nucleus accumbens, a region of the brain implicated in motivation, begins to decrease.
Ceftriaxone appears to block craving by reversing the decrease in GLT1 caused by repeated exposure to cocaine.
A new study conducted by a team of Indiana University neuroscientists demonstrates that GLT1, a protein that clears glutamate from the brain, plays a critical role in the craving for cocaine that develops after only several days of cocaine use.
The study also found a protection for beta cells, namely, a protein called GLT1 that controls glutamate levels outside the beta cells.