SLC1A2

(redirected from GLT1)

SLC1A2

A gene on chromosome 11p13-p12 that encodes solute carrier family 1 member 2, a high-affinity glutamate transporter that plays a key role in transporting glutamate across plasma membranes. In the brain, these transporters clear the excitatory neurotransmitter glutamate from the extracellular space at synapses in the CNS and maintain extracellular glutamate concentrations below neurotoxic levels.

Molecular biology
SLC1A2 mutations are associated with amyotrophic lateral sclerosis.
References in periodicals archive ?
A new study conducted by a team of Indiana University neuroscientists demonstrates that GLT1, a protein that clears glutamate from the brain, plays a critical role in the craving for cocaine that develops after only several days of cocaine use.
The study showed that when rats taking large doses of cocaine are withdrawn from the drug, the production of GLT1 in the nucleus accumbens, a region of the brain implicated in motivation, begins to decrease.
Ceftriaxone appears to block craving by reversing the decrease in GLT1 caused by repeated exposure to cocaine.
The idea is that increasing GLT1 will prevent relapse.
Role of Astrocyte Glutamate Transporter GLT1 in Secondary Loss After SCI
They express the major glutamate transporter, GLT1, and are responsible for the vast majority of glutamate buffering, thereby preventing excess buildup and excito-toxic injury.
This study will examine the role played by astrocyte GLT1 in secondary injury following SCI.
Contralateral cortical response of a subpopulation of interneurons and the glial glutamate transporter GLT1 to an ischemic core
El proposito de este trabajo es analizar los cambios que ocurren en una subpoblacion de interneuronas gabaergicas y en los astrocitos localizados en la corteza cerebral contralateral a un foco isquemico, mediante un anticuerpo contra la proteina atrapadora de calcio parvoalbumina (PV), que es especifica de interneuronas gabaergicas y el transportador glial de glutamato GLT1.
En la poblacion de astrocitos que expresan GLT1, el cual remueve 90% del glutamato presente en las interacciones sinapticas excitatorias.
The study also found a protection for beta cells, namely, a protein called GLT1 that controls glutamate levels outside the beta cells.