MYOC

(redirected from GLC1A)

MYOC

A gene on chromosome 1q23-q24 that encodes myocilin, a protein thought to play a role in cytoskeletal function, which is highly expressed in ocular tissues including the trabecular meshwork, which regulates intraocular pressure.

Molecular pathology
MYOC mutations cause hereditary juvenile-onset open-angle glaucoma.
References in periodicals archive ?
Five of these loci, designated GLC1A to GLC1E, are associated with forms of primary open angle glaucoma and two loci, designated GLC3A and GLC3B associated with PCG.
3 Unknown GLC1A Myocilin 1q21-q23 Homozygous mutations in intron 2 'Syndromes' -- -- 13 Trisomy with PCG -- -- 7 Trisomy -- -- 15 Trisomy