SLC1A3

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SLC1A3

A gene on chromosome 5p13 that encodes solute carrier family 1 member 3, a high-affinity glutamate transporter that plays a key role in transporting glutamate across plasma membranes. In the brain, these transporters clear the excitatory neurotransmitter glutamate from the extracellular space at synapses in the CNS and maintain extracellular glutamate concentrations below neurotoxic levels.
 
Molecular biology
SLC1A3 mutations are associated with episodic ataxia, Type 6.
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