GHR

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GHR

A gene on chromosome 5p13-p12 that encodes growth hormone receptor, a type-I cytokine receptor which, once GH is bound, dimerizes and activates the JAK2/STAT5 transduction pathway, leading to growth.

Molecular pathology
Defects in GHR cause Laron type dwarfism.
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6 10 [micro]g/L GHBP, % (b) [hGH] by immunoassay, [micro]g/L Siemens 9.
GHBP was measured by a modification of a ligand immunofunctional assay (25, 26).
When increasing concentrations of recombinant GHBP were supplemented into samples of low GH [n = 4, mean (SD) 0.
Samples of known endogenous GHBP content (n = 41; range: 203-6503 pmol/L) were analyzed on the iSYS before and after addition of recombinant GH.
GHBP interference can be an issue in GH assays (5) and was therefore systematically investigated in the new iSYS assay.
In summary, we developed a new highly specific automated GH assay that, following recent consensus recommendations, addresses known problems of existing GH immunoassays including heterogeneity of measured GH isoforms and interferences from GHBP and GH analogs.
GH, growth hormone; GHBP, GH binding protein; IDS, Immunodiagnostic Systems; mAbs, monoclonal antibodies; hGH, human GH; LOD, Limits of detection; LOQ, limits of quantification; IGF-1, insulin-like growth factor 1; OGTT, oral glucose tolerance test.
The pool samples were supplemented with GHBP or various GH isoforms to determine their impact on the respective measured GH concentrations.
GHBP was diluted with human serum containing a known GH concentration and with a GHBP concentration of 306 pmol/L.
Assays involving monoclonal antibodies may therefore vary considerably in their ability to detect various isoforms and may react differently with free GH and GH bound to GHBP.
have suggested that GHBP does not contribute substantially to the variability of GH measurements between assays [9].
When all the variables of diverse standards, presence of GH isoforms (monomers, oligomers, fragments) in serum, and variable binding of GH to GHBP are considered, there are obviously many potential sources of variability in GH estimates.