GGH


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GGH

A gene on chromosome 8q12.3 that encodes gamma-glutamyl hydrolase, which progressively removes gamma-glutamyl residues from pteroyl poly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. GGH may play a key role in ensuring the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
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Two study groups consisted of the normal healthy lab volunteers (N-PMN) from TRC and active pulmonary tuberculosis patients (TB-PMN) from GGH with 25 subjects consecutively enrolled in each study group.