GEMIN4

GEMIN4

A gene on chromosome 17p13.3 that encodes gem-associated protein 4, a member of the survival of motor neuron (SMN) complex. The SMN complex plays a key role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus.
References in periodicals archive ?
14) among GEMIN4 rs 1062923 homozygous recessive carriers in response to a 1-SD change in BC, but only 2.
Interactions modifying BC associations were observed with SNPs in the DICER, GEMIN4, and DiGeorge critical region-8 (DGCR8) genes, and in GEMIN3 and GEMIN4, predicting diastolic and systolic BP, respectively.
Although BC interactions with SNPs in DGCR8, DICER, and GEMIN4 were observed in models of DBP, only interactions with single SNPs in GEMIN3 and GEMIN4 were predictive of SBP.
AGO2, GEMIN3, and GEMIN4 then interact with miRNA to form a ribonucleoprotein, which guides the miRNA into the RNA-induced silencing complex (RISC), where the miRNA strand anneals to the 3' untranslated regions (UTRs) of target mRNAs, promoting translational repression or mRNA degradation.
Associations with diastolic blood pressure were modified by SNPs in the DICER, GEMIN4, and DGCR8 genes, and associations with systolic blood presure were modified by SNPs in GEMIN3 and GEMIN4.