GDNF


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GDNF

GDNF

A locus on chromosome 5p13.1-p12 that encodes glial-cell-derived neurotrophic factor, which enhances survival and morphological differentiation of dopaminergic neurons and increases high-affinity dopamine uptake. It is a ligand for the product of the RET (rearranged during transfection) proto-oncogene.

Molecular pathology
GDNF mutations may be associated with Hirschsprung disease.
References in periodicals archive ?
Flence, it could be surmised that somatic cells composing SSCs niche respond to SSCs elimination by upregulation of GDNF and FGF2 and downregulation of KITLG in order to repopulate niche by germ cells.
Reversal of neurochemical changes and pain-related behavior in a model of neuropathic pain using modified lentiviral vectors expressing GDNF.
The tube is linked to a pump placed in the patient's abdomen, which each day delivers GDNF
The catheters are connected to pumps, which are filled with GDNF and continuously infuse the growth factor to this area of the brain.
Dr Gill said it was the capacity of GDNF to repair the nerve cells which become sick and die off in Parkinson's sufferers that was key to the procedure.
But Dr Steven Gill's team now believe they can reverse the degenerative effects of the disease by using GDNF - a growth factor essential to the development of the nerve cells which use a chemical called dopamine to transmit impulses from the brain to the muscles.
They put a drug called GDNF into a pump which feeds it to the most damaged parts of the brain.
Researchers in Bristol put a drug called GDNF into a pump inside the body, which feeds it to the most damaged parts of the brain.
Primary culture of buffalo spermatogonial stem-like cells was treated under different concentrations of FBS and GDNF in cultures plates for 12 days.
GDNF has been pursued as a neuro-regenerative growth factor that holds promise in the treatment of Parkinsons disease, but has met problems in delivery of drug to the affected portions of the diseased brain.
Li, "High glucose promotes cell proliferation and enhances GDNF and RET expression in pancreatic cancer cells," Molecular and Cellular Biochemistry, vol.