All CCAM samples (n = 10) had diffuse or multifocal GDNF
immunostaining in the epithelium lining the cysts, whereas no expression was detected in the endothelial and mesenchymal cells (Figure, e).
which are able to transfect brain cells with an expression plasmid carrying the gene for GDNF
family: signalling, biological functions and therapeutic value.
Gash of the University of Kentucky in Lexington says this preliminary study of GDNF
Mutations in GDNF
and EDNRB have been found previously in the context of mutations in the RET locus (23, 38, 39).
Before long, GDNF
will get a chance to demonstrate its prowess in people with Parkinson's.
, the catheter - developed by Medtronic of Minneapolis - is being used to get the drug directly into the brain.
The researchers discovered that injecting mice with GDNF
seems to shield them from a later administration of MPTP, a compound that kills the same neurons destroyed in Parkinson's disease.
The researchers used a number of methods to gauge GDNF
production, but one was uncommon and involved the novel observation of the rats' weight.
protects these neurons from toxic damage and restores activity to damaged neurons.
She says that her team's previous study showed that both heavy- and light-drinker rats lost at least some of their craving for alcohol upon being administered GDNF
into their brains, and that the protein prevented the animals from relapsing after a period of abstinence.
The researchers said that DFAT cells expressed neurotrophic factors, such as BDNF and GDNF
, prior to and after transplantation and which likely contributed to the promotion of functional recovery.