GDNF


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GDNF

GDNF

A locus on chromosome 5p13.1-p12 that encodes glial-cell-derived neurotrophic factor, which enhances survival and morphological differentiation of dopaminergic neurons and increases high-affinity dopamine uptake. It is a ligand for the product of the RET (rearranged during transfection) proto-oncogene.

Molecular pathology
GDNF mutations may be associated with Hirschsprung disease.
References in periodicals archive ?
All CCAM samples (n = 10) had diffuse or multifocal GDNF immunostaining in the epithelium lining the cysts, whereas no expression was detected in the endothelial and mesenchymal cells (Figure, e).
which are able to transfect brain cells with an expression plasmid carrying the gene for GDNF (pGDNF).
Gash of the University of Kentucky in Lexington says this preliminary study of GDNF is encouraging.
Before long, GDNF will get a chance to demonstrate its prowess in people with Parkinson's.
With GDNF, the catheter - developed by Medtronic of Minneapolis - is being used to get the drug directly into the brain.
The researchers discovered that injecting mice with GDNF seems to shield them from a later administration of MPTP, a compound that kills the same neurons destroyed in Parkinson's disease.
The researchers used a number of methods to gauge GDNF production, but one was uncommon and involved the novel observation of the rats' weight.
GDNF protects these neurons from toxic damage and restores activity to damaged neurons.
She says that her team's previous study showed that both heavy- and light-drinker rats lost at least some of their craving for alcohol upon being administered GDNF into their brains, and that the protein prevented the animals from relapsing after a period of abstinence.
The researchers said that DFAT cells expressed neurotrophic factors, such as BDNF and GDNF, prior to and after transplantation and which likely contributed to the promotion of functional recovery.