GLUD1

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GLUD1

A gene on chromosome 10q23.3 that encodes glutamate dehydrogenase 1, a mitochondrial matrix enzyme which catalyses the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. It plays a key role in regulating amino acid-induced insulin secretion. GLUD1 is allosterically activated by ADP and inhibited by GTP and ATP; it may be involved in learning and memory by increasing the turnover of the neurotransmitter glutamate.

Molecular pathology
Missense mutations of GLUD1 cause hyperinsulinemic hypoglycaemia type 6.
References in periodicals archive ?
Liver biopsy allows direct assessment of enzymatic deficiency, but has several disadvantages: patient discomfort, the risk of an invasive procedure, cost, long turnaround time, and (currently) no source for GDH determination.
Crunchyroll is honored to work with several innovative content companies, such as Akibanana, DLE, GDH and GTChannel to bring their unique content to our passionate community of fans.
It an area that GDH hopes to continue expanding within, and one where CBFM aims to apply its services and play a role in facilitating.
Salinity stress led to a higher increase in the activity of enzyme of the proline biosynthetic pathway in leaves with P-5-CS and GDH (Fig.
Two groups of spring-born calves consigned by GDH Cannon, Bluehill Farm & Messrs J Caygill & Son, Marks Farm sold extremely well to average PS616 topping at PS730.
Sometimes babies with GDH have to be tube fed, but Miller can eat normally and can manage a whole roast dinner
Both parties will collaborate on Guangdong GDH Equipment Technology Industrial Park, the largest investment project in Dongguan.
GDH is the brainchild of founder and CEO, Tarek Al Ashram, and is part of the UAE-based Al Ashram Group of companies.
Both GDH and its owners are very enthusiastic in this endeavour and we are confident that Millennium & Copthorne Hotels is the best fit to run and operate this convention hotel.
Body weight, height and height SDS values Variables GSD 1a GDH 1b Ortalama [+ or -] SS BW (Kg) 21.
The purpose of this study was to evaluate in parallel a few of these methods (ie, EIA, real-time PCR, and GDH assay) in order to assess their analytical and logistical performances and the potential impact of each method on patient management at a 500-bed regional academic medical center.
The archaeal pyruvate and alpha ketoglutarate generated by the action of GDH on glutamate can suppress NFKB producing immunosuppression and decrease in cytokine secretion.