GLI3

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GLI3

A gene on chromosome 7p13 that encodes a DNA-binding C2H2-type zinc finger protein of the Gli family, which plays a role in limb development. The full-length GLI3 (GLI3FL) is a transcriptional activator; GLI3R, the C-terminally truncated form, acts as a repressor of the sonic hedgehog (Shh) pathway.

Molecular pathology
GLI3 mutations are associated with Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, pre-axial polydactyly type IV, and postaxial polydactyly types A1 and B.
References in periodicals archive ?
Other, less common anomalies in GCPS include craniosynostosis, mental retardation, agenesis of the corpus callosum, and umbilical and diaphragmatic hernias.
More than 75% of patients with clinically recognizable GCPS who have been evaluated in the National Institutes of Health (NIH) study have been found to have mutations in GLI3 (1).
The spectrum of GCPS overlaps with that of the so-called non-syndromic preaxial Polydactylies such as preaxial Polydactyly type 4 (11).
IBM has been working with GCPS for over 15 years, most recently being named lead strategic technology partner and chief systems integrator for eCLASS - a digital Content, Learning, Assessment, and Support System.
With the vision of eCLASS now ahead of schedule to be realized, GCPS can serve as a model of how effectively integrating technology into learning can transform education and provide better opportunities for our students as they move onto college and into the workforce, thereby improving our regional and national competitiveness.
As the lead strategic technology partner for GCPS, IBM will continue to oversee the implementation of analytics and mobile capabilities, while delivering digital content via key industry instructional applications and the use of mobile devices.
Our collaboration with GCPS and key partners like Desire2Learn will align data and analytics to truly help teachers and students personalize the learning experience, helping to drive better outcomes," said Michael D.
In addition to the lead banks that provide local banking services in nine countries, GCPS includes 16 "partner banks" that can issue commercial cards in an additional 28 countries.
Headquartered in London and launched in 2001, GCPS provides wide geographic coverage, global reporting and local market expertise through a single core contract, one point of contact, local support and management with centralized monitoring and control.
We have historically used a decentralized management approach, allowing each school to implement its own standards and hardware additions," said Rick Overton, director of Telecommunications & Network Operations with GCPS.
GCPS is one of the fastest growing school systems in the country, with more than 96 schools and 22,000 teachers, administrators and staff serving a student population projected to reach nearly 150,000 by 2006.
To meet rising and future demand, GCPS conducted an in-depth evaluation of its IT systems, targeting service-level optimization for its growing student population, the eight new schools opened in 2003, along with ten additional schools planned for 2004.