FOLH1

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FOLH1

A gene on chromosome 11p11.2 that encodes folate hydrolase 1, which has both folate hydrolase (FH) and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. It acts as an FH in the intestine and is required for the uptake of folate; in the brain, it modulates excitatory neurotransmission by hydrolysing the neuropeptide N-aceylaspartylglutamate (NAAG), releasing glutamate. It is highly expressed in the prostate.
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BSI") related to Eisai's GCPII (glutamate carboxypeptidase II) technology.
rights to utilize Eisai's GCPII technology to generate GCPII inhibitor molecules for diseases of the central nervous system, including peripheral neuropathy, Alzheimer's disease, stroke, ALS, neurodegeneration and other disorders in humans.
GCPII (NAALADase) Inhibition Partially Reverses Nerve Conduction Velocity Deficits, Hyperalgesia and Morphological Abnormalities Following Chronic Diabetes in BB/Wor Rats.