GCK


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GCK

A gene on chromosome 7p15.3-p15.1 that encodes a glucokinase (hexokinase) that phosphorylates glucose yielding glucose-6-phosphate, the first usual step in glucose metabolism.

Molecular biology
GCK mutations are linked to type-2 diabetes, maturity-onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycaemia of infancy (PHHI).
References in periodicals archive ?
Conversely, this study found that teachers with teaching experience of less than 10 years tended to perceive higher self-efficacy in their GK, GCK, GPK and GPCK than those with teaching experience of 11 to 20 years (see Table 1).
Typically, however, patients with GCK MODY are treated--inappropriately--with insulin or oral hypoglycemic agents because they have been misdiagnosed as having type 2 or less commonly type 1 diabetes.
Of note, syndromes with renal dysplasia are considered under obstructive GCK (Table 1).
Maturity-onset diabetes of the young (MODY) Tipe Mutation How common MODY 1 HNF4A Hepatocyte Rare nuclear factor 4 [alpha] MODY 2 GCK Glucokinase MODY 2 is the second-most common form of MODY MODY 3 TCF1 Hepatic nuclear Rare factor 1 [alpha] or HNF1 [alpha] or HNF1A MODY 3 is the most common form of MODY.
She established her own firm, GCK Consulting, in 2002.
Genetic testing is available through commercial laboratories for 4 of the 6 genes known to be associated with HI (ABCC8, KCNJ11, GCK, GLUD-1).
PWC National's vice president of corporate development, Gwendolyn Colbert Kushner, the principal of GCK Consulting of NY, LLC, is reprising her role as event chair of PWC's Oct.
Routine mutation screening of HNF-1 and GCK genes in MODY diagnosis: how effective are the techniques of DHPLC and direct sequencing used in combination?
PWC Vice President of Development Gwendolyn Colbert Kushner, also the president of GCK Consulting, introduced Career Achievement Award honoree Lea Pi, construction project manager with CapitalOne Bank, as someone who "exemplifies the mission of PWC.
The 12 GCK exons [6] were amplified by PCR (fragments ranging from 145 to 367 bp), as reported previously [2], either on GeneampE' 9600 (Perkin-Elmer) or PTC100[TM] (MJ Research) DNA thermal cyclers.
Awards presenters include PWC President Lenore Janis; Michele Medaglia, president, ACC Construction; Gwendolyn Colbert Kushner, PWC vice president corporate development and president of GCK Consulting of NY, LLC; and Linda Christensen, senior vice president & general counsel, Tishman Realty & Construction Co.
To date, researchers at 12 of the top 20 pharmaceutical research organizations, 6 of the top 10 biotechnology companies and many of the leading research universities utilize GCK.