SERPINA9

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SERPINA9

A gene on chromosome 14q32.13 that encodes a member of the serine protease inhibitor (serpin) family which, in vitro, inhibits trypsin and trypsin-like serine proteases and, with lower efficiency, plasmin and thrombin.
References in periodicals archive ?
Among these 3 markers, GCET1 shows the highest specificity for FL (60% of cases).
By adding GCET1 and FOXP1, Choi et al (66) increased the concordance of immunohistochemical classification of GC versus non-GC to 93%, as compared with gene expression profiling.
Diagnostic utility of the germinal center-associated markers GCET1, HGAL, and LMO2 in hematolymphoid neoplasms.
Posteriormente se desarrollaron algoritmos con algunas modificaciones como el algoritmo de CHOI, en el que se incluye la expresion de FOXP1 [Forkhead boxprotein 1: es un factor de transcripcion alas helice que actua como un represor transcripcional que se expresa tanto en tejido normal como tejido neoplasico y se expresa en celulas linfoides B pero no en celulas plasmaticas (10, 12)] y GCET1 [Germinal center B-cell expressed transcript-1 gene codifica para una proteina expresada en las celulas B centrogerminales (12)], que se correlacionado con el perfil de expresion genica en algunos estudios hasta en un 87% de los casos.
Other systems use combinations of other markers ([Choi et al (45): GCET1, MUM1, CD10, BCL6, FOXP1], [Muris et al (48): BCL2, CD10, MUM1], [Natkunam et al (49): LMO2], [Nyman et al (50): MUM1, FOXP1], and [Meyer et al (51): CD10, GCET1, MUM1, FOXP1, LMO2]) to achieve a more accurate prediction of the gene expression profile results (Figure 3, a through n).
The BL cells consistently express germinal center-associated markers including BCL6, GCET1, and HGAL.
Other commonly used immunohistochemical cell-of-origin classification schemes include the algorithm by Choi et al (57) (Figure, B), in which 2 to 4 immunohistochemical stains are evaluated (including GCET1, MUM1, CD10, BCL6, and FOXP1), and a tally algorithm56 (Figure, C), which uses 4 to 5 immunohistochemical stains (including CD10, GCET1, MUM1, FOXP1, and LMO2).
Other markers, including BCL6, human germinal center-associated lymphoma (HGAL also known as GCET2) antigen, (50) or GCET1, may be used as alternatives.
Immunohistochemistry of GCET1 shows a granular cytoplasmic stain pattern.