GATA6

GATA6

A gene on chromosome 18q11.1-q11.2 that encodes a member of the GATA family of zinc finger transcription factors, which is thought to play a key role in regulating proliferation and terminal differentiation.
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An international team of researchers led by scientists from the Peninsula College of Medicine and Dentistry at the University of Exeter report a mutation in the gene GATA6 found in fifteen out of twenty-seven individuals with pancreatic agenesis.
The finding was particularly surprising as switching off the GATA6 gene in mouse models appeared to make no difference to the development of the pancreas.
Our study suggests that GATA6 plays a very important role in this process and we hope this will help the crucial work to try and make beta-cells for patients with type 1 diabetes," Andrew Hattersley from the Peninsula College of Medicine and Dentistry, said.
13,14) Amplifications of other oncogenes such as CMYC7, (15) and GATA6 (15,16) are less frequent.
Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer.
GATA6 regulates differentiation of distal lung epithelium.
III] Chemokine (C-C motif) ligand 2 CCL2 Cell-cell signaling Collagen, type I, alpha 1 COL1A1 Extracellular matrix Connexin 43 GJA1 Cell-cell signaling GATA binding protein 6 GATA6 Transcription factor activity Insulin-like growth factor IGFBP5 Regulation of binding protein 5 cell growth Integrin, beta 3 ITGB3 Cell-matrix adhesion Matrix metalloproteinase 2 MMP2 Metallopeptidase activity Myosin, light polypeptide kinase MYLK Protein kinase activity Nucleoporin 88 kDa NUP88 Nuclear pore Protein kinase C, alpha PRKCA Cell proliferation Homo sapiens PAC clone RP5-1057Ml Unknown from 7, complete sequence [MMA.