GATA6

GATA6

A gene on chromosome 18q11.1-q11.2 that encodes a member of the GATA family of zinc finger transcription factors, which is thought to play a key role in regulating proliferation and terminal differentiation.
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Noninvasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate.
GATA6 gene transcription and the stability of messenger RNA (mRNA) were reported to be increased in PCOS theca cells.
MiRNAs which may interact with CYP17, GATA6, IRS-2, and glycogen synthase kinase-3[sz] (GSK3[sz]) were searched using TargetScan 6.
Prediction results [Figure 1] and [Table 4] demonstrated that the putative target genes of the above miRNAs include CYP17, GATA6, and IRS-2.
Synergistic Induction of DOC-2/DAB2 Gene Expression in Transitional Cell Carcinoma in the Presence of GATA6 and Histone Deacetylase Inhibitor.
M Yamamure E, Joo K et al GATA6 Mutation causes human cardiac outflow tract defect by disrupting semaphoriin-plexin signaling.
An international team of researchers led by scientists from the Peninsula College of Medicine and Dentistry at the University of Exeter report a mutation in the gene GATA6 found in fifteen out of twenty-seven individuals with pancreatic agenesis.
The study, funded by organisations including the Wellcome Trust, Diabetes UK and the National Institute for Health Research, establishes a key role for GATA6 in the development of pancreatic cells.
13,14) Amplifications of other oncogenes such as CMYC7, (15) and GATA6 (15,16) are less frequent.
Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer.
GATA6 regulates differentiation of distal lung epithelium.
III] Chemokine (C-C motif) ligand 2 CCL2 Cell-cell signaling Collagen, type I, alpha 1 COL1A1 Extracellular matrix Connexin 43 GJA1 Cell-cell signaling GATA binding protein 6 GATA6 Transcription factor activity Insulin-like growth factor IGFBP5 Regulation of binding protein 5 cell growth Integrin, beta 3 ITGB3 Cell-matrix adhesion Matrix metalloproteinase 2 MMP2 Metallopeptidase activity Myosin, light polypeptide kinase MYLK Protein kinase activity Nucleoporin 88 kDa NUP88 Nuclear pore Protein kinase C, alpha PRKCA Cell proliferation Homo sapiens PAC clone RP5-1057Ml Unknown from 7, complete sequence [MMA.