GATA4

GATA4

A gene on chromosome 8p23.1-p22 that encodes a member of the GATA family of zinc finger transcription factors, which recognise presence of the GATA motif in gene promoters. GATA4 protein may regulate genes involved in embryogenesis and myocardial differentiation and function.
 
Molecular pathology
GATA4 mutations may cause cardiac septal defects.
References in periodicals archive ?
While these cells containing GATA4 are located in the end portions of the pancreatic bud, the cells containing GATA4 and SOX9 settle in the body of the pancreas (51).
Cardiopathogenic mediators generated by GATA4 signaling upon co-activation with endothelin-1 and Trypanosoma cruzi infection.
A recent study of OSCC tumors from German OSCC patients suggests that ALH1A2, OSR2, GATA4, GRIA4, and IRX4 gene transcription is regulated by gene-promoter hypermethylation, which in turn correlates with HPV status in OSCC tumors (22).
Scientists discovered that the GATA4 protein acts like a biochemical switch and forces cells to stop growing and dividing, Sarah Schwartz reported in "Protein buildup triggers cellular aging" (SN: 10/31/15, p.
5, GATA4, and GATA6) [77], they differ from adult ventricular cardiomyocytes in a number of properties.
5 and the zinc finger transcription factor GATA4 as early markers of cardiac differentiation [24, 25], and activated leukocyte cell adhesion molecule (CD166, ALCAM) as a marker of cardiomyocytes [26].
48,49) Other tumor suppressor genes frequently hypermethylated in OPSCC and other smoking-related cancers include RARb, (50-53) RASSFI, (44,54,55) MGMT, (10,47,50,56,57) and GATA4.
Another study examined a polymorphism associated with a gene called GATA4, which encodes a transcription factor for atrial natriuretic peptide and has been associated with alcohol addiction (Kiefer et al.
a (30,31) (a possible ortholog of vertebrate GATA4, GATA5, and GATA6; the original name was Gata-a), and the Zic-like protein Macho-1/Zic-r.
Mutations in the GATA4 gen in patients with non-syndromic congenital heart disease.
Feed-back regulation of disabled-2 (Dab2) p96 isoform for GATA4 during differentiation of F9 cells.
5 and GATA4 nuclear translocation in tissue-specific mesenchymal stem cells.