GATA3


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GATA3

A gene on chromosome 10p15 that encodes a zinc finger protein belonging to the GATA family of transcription factors, which is a key regulator of T-cell development and plays an important role in endothelial cell biology.

Molecular pathology
GATA3 mutations cause hypoparathyroidism with sensorineural deafness and renal dysplasia.
References in periodicals archive ?
001, respectively), whereas GATA3 increased significantly in the 10-[micro]g/kg body weight group (Figure 7B;p < 0.
The tumour cells were negative for ER, PR, GATA3, GCDFP-15, CD56, synaptophysin and chromogranin.
TNBS significantly induced expression of IL-17, IFN-[gamma], ROR[gamma]t, and T-bet and suppressed expression of IL-10, IL-5, Foxp3, and GATA3.
Caption: Figure 5: Immunohistochemistry: CK7, p63, and GATA3 expression in malignant cells, consistent with transitional cell differentiation.
The Transcription Factor GATA3 actively represses RUNX3 protein-regulated production of interferon-[gamma].
This variant is located on the same chromosome 10 region that includes GATA3, a transcription factor gene previously linked to several forms of cancer.
Thl7 cells are a distinct linage from Thl or Th2 cells; the transcriptional factor ROR-yt directs development of Th17 cells, while T-bet and GATA3 induce the development of Thl and Th2 cells, respectively, and inhibit differentiation of Thl 7 cells.
It is interesting to note that FoxA1 is known to be a downstream target of GATA3, a transcription factor involved in mammary gland development including formation of the terminal end buds during puberty and luminal cell differentiation.
24) The most specific markers for a breast primary are GATA3, mammaglobin, and GCDFP15, for which secondary tumors are consistently negative.
Furthermore, an overview of thirty HDR syndrome families with corresponding GATA3 mutations revealed that hearing impairment occurred earlier in the younger generation in at least nine familial cases (30%) and two thirds of them were found to carry premature stop mutations.
The following inventoried primes/probes tested by Life Technologies were used: [beta]-actin (Mm00607939_s1), T-bet (Mm00450960_m1), GATA3 (Mm00484683_m1), ROR-[gamma] (Mm01261022_m1), and Foxp3 (Mm00475162_m1).