GATA1


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GATA1

A gene on chromosome Xp11.23 that encodes a protein of the GATA family of transcription factors, which plays a key role in erythroid development by regulating the switch of foetal to adult haemoglobin.

Molecular pathology
GATA1 mutation is associated with X-linked dyserythropoietic anaemia and thrombocytopaenia.
References in periodicals archive ?
In theoretical models of common myeloid precursor cells choosing between either the erythroid or myelomonocytic fate, gene circuits involving GATA1 and PU.
When the transcription factor was activated, rodents exhibited depressive-like symptoms, suggesting GATA1 plays a role not only in the loss of connections between neurons but also in symptoms of depression.
Duman theorizes that genetic variations in GATA1 may one day help identify people at high risk for major depression or sensitivity to stress.
The increased incidence of this leukemia in children with Down syndrome convinced the researchers that a GATA1 mutation may be joining forces with some genetic factor on chromosome 21 -- specifically, miR-125b-2.
The researchers then used a virus to over-express miR-125b-2 in these cells and compared them to MEP and MP cells without a GATA1 mutation.
Although over-expression of miR-125b-2 caused increased growth and replication of MEP and MP cells with or without the GATA1 mutation, the growth was further enhanced in the presence of the GATA1 mutation.
Moreover, acetylation of other crucial transcription factors like E2F, GATA1 at sites adjacent to DNA binding domain enhances the transcriptional activity whereas acetylation at sites within the DNA binding domain disrupts the DNA binding, e.
Five years ago, researchers reported that one-fifth of people with Down syndrome who have acute myeloid leukemia have a mutation in a gene called GATA1 on the X chromosome.
We think trisomy in chromosome 21 gives a survival advantage to cells carrying the JAK2 or GATA1 mutations," Izraeli says.
GATA1 (GATA binding protein 1) is essential for normal erythropoiesis, with a crucial role in cell survival and maturation (13).
We used transcript concentrations of marker genes GATA1, RUNX1, SPI1, and NCAM1, commonly involved in leukemogenesis, to study the need for stabilization of BM samples in a clinical setting of disease monitoring.
Q-RT-PCR was performed in a 1-step method with 1 ng total RNA by use of the Quantitect[R] SYBR[R] Green reverse-transcription (RT)-PCR Kit and Quantitect Primer Assays (Qiagen) for the detection of GATA1, RUNX1, NCAM1, and SPI1 and for control gene 18S rRNA.