GAS5

GAS5

An RNA gene on chromosome 1q25.1 that belongs to the so-called ORGUL (Overlapping RNA Genes unified location) cluster, which includes snoRNA and C_D_box_snoRNA.
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To elucidate the mechanism underlying this effect, we also examined the impact of ISO treatment on the expression of the miRNAs miR-1, miR-21, and miR-210 and the lncRNAs MALAT1, MEG3, and GAS5.
In contrast, GAS5 and MEG3 expression decreased (0.
Moreover, the expression of GAS5 and MEG3 significantly declined (0.
Furthermore, we found that ISO upregulated the levels of miR-210, miR-21, and miR-1 and downregulated those of the lncRNAs MEG3 and GAS5, indicating that ISO-mediated angiogenesis might be associated with the regulation of noncoding RNAs.
MEG3 is thought to inhibit this process by reducing VEGF levels,[sup][14] and GAS5 knockdown increases retinal neovascularization and capillary leakage.
sup][24] HIF-1a also augments the expression of miR-21,[sup][17] which inhibits GAS5.
In the present study, ISO exerted a minor stimulatory effect on HUVEC proliferation, which might be associated with the inhibition of GAS5 and MEG3 expression observed.
In conclusion, ISO-mediated angiogenesis was found to be associated with the regulation of noncoding RNAs, including the miRNAs miR-210 and miR-21 and the lncRNAs GAS5 and MEG3.
Molecular and cellular mechanisms of action of tumour suppressor GAS5 LncRNA.