GAPDH

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GAPDH

A gene on chromosome 12p13 that encodes glyceraldehyde-3-phosphate dehydrogenase, which has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities. It catalyses the reversible
oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide, an important energy-yielding step in carbohydrate metabolism. GADPH participates in nuclear events, including transcription, RNA transport, DNA replication and apoptosis.
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The interassay CV of the TagMan assay was 15%-45% with GAPD as an external standard and 10%42% with GAPD multiplexing.
For FFPE sample analysis, however, Try, MMP7, uPA, and GAPD did not amplify in the TagMan assay, possibly because of the relatively long PCR amplicons for these genes (interval, 101-122 bp).
Distinct patterns of gene expression were observed in different anatomic regions: GAPD was consistently highly expressed in all regions.
The GAPD enzyme is also involved in neuronal apoptosis, or the programmed death of brain cells.
Last month, scientists in France reported that GAPD also has a role in modifying a receptor (GABAa) involved in the transmission of signals between nerves.
The combination of our association of GAPD and Alzheimer's disease along with these recently published findings on GAPD and its role in neurotransmission may ultimately lead to better methods of treatment and targeted therapies for neurological disorders.