GALOP syndrome

A cerebellar disorder characterised by the acronym, GALOP:

Gait ataxia
Autoantibodies IgM GD1a autoantibody against central myelin antigen
Late age of Onset
Polyneuropathy, sensory > motor, symmetric
Management Cyclophosphamide, human Ig

GALOP syndrome

Neurology A cerebellar disorder characterized by the acronym, GALOP: Gait disorder–ataxia, Autoantibodies–IgM against central myelin antigen; Late age of Onset; Polyneuropathy, sensory > motor, symmetric Management Cyclophosphamide, human Ig
Mentioned in ?
References in periodicals archive ?
7,8) identified a subgroup of older patients with peripheral neuropathy, gait ataxia, and elevated titers of serum immunoglobulin M (IgM) binding to galopin and used the term GALOP syndrome (Gait disorder, Antibody, Late-age Onset, Polyneuropathy) to delineate common features among these patients.
In this issue of the Southern Medical Journal, Alpert (9) reports the first case of GALOP syndrome with a 7-year follow-up.
The patient's favorable therapeutic response to IV Ig, which was associated with a drop in antisulfatide antibody titers, further emphasizes the role of the immune system in the pathogenesis of GALOP syndrome and the significance of chronic immunosuppression in management of these patients.
In conclusion, a diagnosis of GALOP syndrome should be strongly considered in elderly patients with peripheral neuropathy and otherwise idiopathic gait dysfunction, since it may be treatable with IV Ig.
Key Words: GALOP syndrome, late-onset polyneuropathy, monoclonal gammopathy
Abstract: An elderly woman complaining of a gait disorder was found to have the GALOP syndrome (gait ataxia, late-onset polyneuropathy).
There are only two reports (1,2) and one review (3) describing a total of 15 patients who exhibited the GALOP syndrome (gait ataxia late-onset polyneuropathy).