GADD45A

GADD45A

A gene on chromosome 1p31.2 that is upregulated in response to stressful growth-arrest conditions and exposure to DNA-damaging agents. The encoded protein activates the p38/JNK pathway via MTK1/MEKK4 kinase.
References in periodicals archive ?
Eight of these genes (PAI-1, BNIP3l, VEGF, NSE, RGS4, HSP27, GADD45A, PTPN14) were validated in a semiquantitative immunohistochemical analysis, and overexpression analyses revealed 66 significantly dysregulated pathways associated with cell proliferation, cell stress, cell communication, and metabolic and cytokine function.
Combined GADD45A and thymidine phosphorylase expression levels predict response and survival of neoadjuvant-treated gastric cancer patients.
The study is entitled "Estrogen receptor beta causes a G2 cell cycle arrest by inhibiting CDK1 activity through the regulation of cyclin B1, GADD45A, and BTG2", in the journal Breast Cancer Research and Treatment.