EPCAM

(redirected from GA733-2)

EPCAM

A gene on chromosome 2p21 that encodes a carcinoma-associated antigen expressed on most normal epithelial cells and gastrointestinal carcinomas, which functions as a homotypic calcium-independent cell adhesion molecule. EPCAM is thought to function as a relay molecule between intestinal epithelial cells and intraepithelial lymphocytes at the mucosa, providing an immune barrier to infection. It is of interest in oncology as a target for cancer immunotherapy. It upregulates expression of FABP5, MYC and cyclins A and E.

Molecular pathology
Defects in EPCAM cause congenital tufting enteropathy (diarrhoea type 5).
References in periodicals archive ?
Ye and Shi (75) found changes in genes involved in carcinogenesis such as Src, MAPK and its related proteins, cell cycle regulation, checkpoint suppressor 1, wnt-13 and carcinoma-associated antigen GA733-2 after a 2 h exposure to 300 [micro]M soluble chromate in human lung tumour cells.
5 mg/kg Expression of 56 genes increased intratracheal in lung after Cr exposure instillation Genes involved in Cr(VI) metabolism, 3 days stress response, protein and DNA repair, signal transduction, apoptosis and cell cycle regulation were altered Potassium Activation of genes involved in 75 dichromate tumourigenesis included NEN-1, cystatin 300 [micro]M M, carcinoma-associated antigen GA733-2, 2 h breast tumour anti-antigen, checkpoint suppressor I, wnt-13 and cytochrome c-like polypeptide Sodium dichromate Chromium altered the expression of 44 76 10 [micro]M genes 4 h Changes in mRNA expression induced changes at the protein level Table IVd.