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G6PD |
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G6PD glucose-6-phosphate dehydrogenase. glucose-6-phosphate dehydrogenase (G6PD) deficiency, an inherited disorder characterized by red cells partially or completely deficient in G6PD, an enzyme critical in aerobic glycolysis. A sex-linked disorder, the defect is fully expressed in affected males despite a heterozygous pattern of inheritance. The disorder is associated with episodes of acute hemolysis under conditions of stress or in response to certain chemicals or drugs. The anemia that results is a kind of nonspherocytic hemolytic anemia. See also congenital nonspherocytic hemolytic anemia, favism. glucose-6-phosphate dehydrogenase (G6PD) test, a blood test to diagnose G6PD deficiency in suspected individuals. Deficiency of this enzyme causes precipitation of hemoglobin and cellular membrane changes, possibly resulting in hemolysis of variable severity, a sex-linked trait carried on the X chromosome. G6PD glucose-6-phosphate dehydrogenase. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Previously, underlying defects in host defense, especially of neutrophils, have been hypothesized to predispose to infection: cases have been reported in patients with chronic granulomatous disease (13) and G6PD deficiency (14). Her blood count and G6PD level were normal, so we increased the dapsone dosage to 50 mg twice daily. The mutations can cause G6PD deficiency and result in life-threatening anemia. |
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