ISG15

(redirected from G1P2)

ISG15

A gene on chromosome 1p36.33 that encodes a ubiquitin-like protein which binds to target proteins in response to IFN-alpha or IFN-beta stimulation. ISG15 has chemotactic activity on neutrophils and activates them, triggering their release of eosinophil chemotactic factors. It may: play a role as a trans-acting binding factor, directing ligated target proteins to bind to intermediate filaments; have autocrine, paracrine and endocrine effects, including cell-to-cell signalling, possibly by inducing IFN-gamma secretion by macrophages; respond to IFN-tau secreted by the foetus; and bind and regulate proteins involved in the release of prostaglandin F2-alpha, preventing lysis of the corpus luteum and maintaining the pregnancy.
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CASE REPORT: A 25 years old female G1P2, weighing 55 kg was admitted for delivery.
04 protein 2 (1-8D) G1P2 Interferon, [alpha]-inducible 9.
The other confirmed transcriptionally up-regulated genes may be associated with cervical disease: G1P2 (interferon-stimulated protein; 15-kDa) may be overproduced as a result of infection (24), and KRT14 and KRT16 (keratin 14 and 16) are produced at high concentrations in the keratinizing squamous epithelium of the cervix.