ISG15

(redirected from G1P2)

ISG15

A gene on chromosome 1p36.33 that encodes a ubiquitin-like protein which binds to target proteins in response to IFN-alpha or IFN-beta stimulation. ISG15 has chemotactic activity on neutrophils and activates them, triggering their release of eosinophil chemotactic factors. It may: play a role as a trans-acting binding factor, directing ligated target proteins to bind to intermediate filaments; have autocrine, paracrine and endocrine effects, including cell-to-cell signalling, possibly by inducing IFN-gamma secretion by macrophages; respond to IFN-tau secreted by the foetus; and bind and regulate proteins involved in the release of prostaglandin F2-alpha, preventing lysis of the corpus luteum and maintaining the pregnancy.
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04 protein 2 (1-8D) G1P2 Interferon, [alpha]-inducible 9.
The other confirmed transcriptionally up-regulated genes may be associated with cervical disease: G1P2 (interferon-stimulated protein; 15-kDa) may be overproduced as a result of infection (24), and KRT14 and KRT16 (keratin 14 and 16) are produced at high concentrations in the keratinizing squamous epithelium of the cervix.
Patient identifier (b) Gene symbol (a) Pt 1 (c) Pt 2 Pt 3 Pt 4 Pt 5 CCNB1 +++ +++ + ++ +++ KRT14 +++ +++ + ++ +++ KARS +++ = + +++ + KRT16 ++ +++ = = +++ OAZ1 + +++ ++ ++ +++ SPINT2 + +++ + +++ +++ ZWINT ++ +++ +++ * +++ G1P2 +++ +++ ++ - - - +++ AURKB + 0 + = +++ CDCA8 ++ 0 + = + HPV16E7 +++ +++ 0 + 0 Patient identifier (b) Patients with up-regulated Gene symbol (a) Pt 6 Pt 7 Pt 8 gene, (d) n CCNB1 +++ + ++ 8 KRT14 = +++ + 7 KARS +++ +++ -- 6 KRT16 +++ +++ +++ 6 OAZ1 ++ = = 6 SPINT2 +++ = -- 6 ZWINT = +++ + 6 G1P2 - - 0 +++ 5 AURKB ++ 0 0 4 CDCA8 + 0 0 4 HPV16E7 +++ 0 0 4 (a) Genes listed were chosen for analysis by TagMan.