As previously reported, SKs are composed of hyperadherent senescent cells that are arrested in the G1 phase of the cell cycle
Cellular senescence is due to cycle arrest in the G1 phase of the cell cycle
in response to physiological levels of mitogens.
The use of natural compounds that stop cancer in G1 phase of the cell cycle
may provide an alternative to 5-FU drug regime.
Importantly we observed that ZFX knockdown caused cell cycle arrest at the G1 phase of the cell cycle
evidenced by the accumulation of G1 phase cells and decrease in S and G2/M phase.
At the end of the process, the cells still have the ability to interact with the environment, but remain permanently in the G1 phase of the cell cycle
, not responding to physiologic stimuli for progression in the cycle or for DNA synthesis (LI et al.
Factors modulating exit from G0 and progression through G1 phase of the cell cycle
are critical in determining overall growth rates of cells.
During the G1 phase of the cell cycle
cells increase in size, produce RNA, and synthesize protein.
CXS299 selectively blocks tumor cells in G1 phase of the cell cycle
, which makes the agent unique, more potent and less prone to cross-resistance compared to approved platinum therapies.
Similarly, ARG increased the proportion of cells in the G1 phase of the cell cycle
in A549 cancer cells and induced [G.
Because D-type cyclins are required for the progression of cells from the G1 phase of the cell cycle
to the S phase (Matsushime et al.