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G-CSF

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G-CSF granulocyte colony-stimulating factor.
G-CSF,
G-CSF
granulocyte-colony stimulating factor.

G-CSF
Granulocyte colony-stimulating factor Molecular therapeutics A biological response modifier, the recombinant DNA form of which is filgrastim–Neupogen® Activity G-CSF stimulates granulocyte production in BM suppressed by chemotherapy, RT, serving to ↓ infections in Pts with malignancy; G-CSF can induce terminal maturation of myeloid leukemia cell lines and suppress self-renewal, and is thus useful in Pts with AIDS or leukemic relapse after allogeneic BMT Adverse effects Nausea, bone pain, rash. See Biological response modifiers, Colony-stimulating factors. Cf GM-CSF.


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During the five days before the collection, the donor receives daily injections of the naturally occurring hormone granulocyte colony stimulating factor or G-CSF to mobilise their blood stem cells.
In the study, researchers examined the impact of G-CSF on bone development in mice.
Beyond intracoronary infusion of autologous bone marrow mononuclear CD34+ cells (MNCCD34+), mobilization of stem cells by G-CSF has recently attracted attention because of various advantages such as the noninvasive nature of MNCCD34+ mobilization by subcutaneous injections.
 
 
 
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