G-CSF


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G-CSF

G-CSF

granulocyte colony-stimulating factor.

G-CSF

G-CSF

A biological response modifier encoded by CSF3 on chromosome 17q11.2-q12, which is produced by endothelial cells, fibroblasts, and macrophages. It stimulates granulocyte production in bone marrow (BM), acting synergistically with IL-3 to stimulate proliferation of other marrow cells. The recombinant DNA form is filgrastim (Neupogen).
 
Activity
G-CSF stimulates granulocyte production in BM suppressed by chemotherapy and radiotherapy, and reduces infections in cancer patients. It can induce terminal maturation of myeloid leukaemia cells, resulting in complete haematologic and cytologic remission, and can suppress self-renewal. It is useful in patients with AIDS or leukaemic relapse after allogeneic BM transplantation.
 
Adverse effects
Nausea, bone pain, rash.

G-CSF

Granulocyte colony-stimulating factor Molecular therapeutics A biological response modifier, the recombinant DNA form of which is filgrastim–Neupogen® Activity G-CSF stimulates granulocyte production in BM suppressed by chemotherapy, RT, serving to ↓ infections in Pts with malignancy; G-CSF can induce terminal maturation of myeloid leukemia cell lines and suppress self-renewal, and is thus useful in Pts with AIDS or leukemic relapse after allogeneic BMT Adverse effects Nausea, bone pain, rash. See Biological response modifiers, Colony-stimulating factors. Cf GM-CSF.

G-CSF

Abbreviation for granulocyte colony-stimulating factor.

granulocyte colony-stimulating factor

; G-CSF; granulocyte-macrophage colony-stimulating factor; GM-CSF cytokines that promote bone marrow cell mitosis

G-CSF

granulocyte-colony stimulating factor.
References in periodicals archive ?
They indeed confirm and underline the potential mechanism of G-CSF induced inhibition of apoptosis and prevention of adverse remodeling as described in our review (1).
Read the full report: The World Market for Biosimlars (EPO, G-CSF, HGH, Insulin, Interferon Alpha, Monoclonal Antibodies, Other), 4th Edition https://www.
Kemik iliginin otolog mononukleer CD34+ hucrelerin (MNCCD34+) intrakoroner infuzyonun otesinde, kok hucrelerin G-CSF araciligi ile mobilizasyonu son zamanlarda noninvazif subkutan enjeksiyonlu MNCCD34+ mobilizasyonu gibi farkli avantajlar nedeni ile dikkati uzerine gekmistir.
Therefore, given the lack of studies showing that use of erythropoietin and G-CSF result in improved SVR compared with dosage reduction, routine use of growth factors should be discouraged.
9 pg/mL for maternal serum G-CSF, which had a sensitivity of 63% and a specificity of 79% for predicting funisitis.
Mozobil may also reduce the number of patients who require a second mobilization procedure due to a failure to mobilize sufficient numbers of cells with current therapy of G-CSF alone.
That is why we worked with IBPL to successfully complete a phase I clinical trial and have transferred our rights in IBPL's G-CSF to Apotex including initiation of a phase III trial for the approval of G-CSF in Europe.
Our report analyzes the market for the global G-CSF biosimilars and looks into the recent activities in the segment.
To assess the safety and tolerability of subcutaneous doses of ATL1102 alone, and in combination with G-CSF in healthy volunteers
Tbo-filgrastim is a short-acting recombinant type of G-CSF, indicated to decrease the duration of severe neutropenia in patients who suffer from certain kind of cancer (non-myeloid malignancies) who are on chemotherapy that affects the bone marrow.
The study compared hematopoietic stem cell yield from patients treated with Mozobil in combination with G-CSF to patients treated with G-CSF in combination with placebo.
Amgen's '804 patent includes certain claims to mutated granulocyte colony stimulating factor (G-CSF) molecules that potentially cover Maxygen's MAXY-G34 product candidate, a next-generation, pegylated G-CSF.