G protein

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G protein

A cellular protein activated by the binding of an intercellular signal to its receptor on the cell membrane; the G-protein then activates the enzyme adenyl cyclase within the cell, triggering the formation of cyclic AMP and a stereotyped response.
See also: protein

G protein

a regulatory protein which becomes activated when bound to GTP and is involved in signal transduction.

G protein coupled receptor
a member of a large class of cell-surface signaling receptors that contain seven transmembrane a helices; ligand binding results in activation of a coupled trimeric G protein that then initiates intracellular signal transduction pathways.
References in periodicals archive ?
Patent and Trademark Office (USPTO) recently awarded Stanford University another important patent covering methods of analyzing G protein coupled receptor (GPCR) crystal structures and selecting GPCR modulators using the proprietary T4-lysozyme (T4-L) fusion technology.
The vector contains a first segment comprising at least a fragment of the extreme amino-terminal coding sequence of a yeast G protein coupled receptor.
This achievement represents rapid progress for the collaboration, which was launched in September 2010 to develop G protein coupled receptor (GPCR)-targeted therapeutic compounds utilizing Anchor's proprietary pepducin technology.
Promics' technology focuses on developing drugs that target C5a and G protein coupled receptors, critically important receptors found in most parts of the body.
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