G protein

(redirected from G protein coupled receptor)
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G protein

A cellular protein activated by the binding of an intercellular signal to its receptor on the cell membrane; the G-protein then activates the enzyme adenyl cyclase within the cell, triggering the formation of cyclic AMP and a stereotyped response.
See also: protein

G protein

a regulatory protein which becomes activated when bound to GTP and is involved in signal transduction.

G protein coupled receptor
a member of a large class of cell-surface signaling receptors that contain seven transmembrane a helices; ligand binding results in activation of a coupled trimeric G protein that then initiates intracellular signal transduction pathways.
References in periodicals archive ?
Pepducins are lipidated peptides designed to be allosteric modulators for G protein coupled receptor (GPCR) targets, especially those intractable to current approaches.
RuiYi's scientific founder and iHuman Institute founding director, Ray Stevens, said, 'The evolution and power of RuiYi's iCAPS technology enables the generation of antibodies to GPCRs with great selectivity, which can be used not only for antibody therapeutic development but also for probing the structure, function, chemical probe discovery, and signaling pathways of G protein coupled receptors.
Promics' technology focuses on developing drugs that target C5a and G protein coupled receptors, critically important receptors found in most parts of the body.
Shifting Paradigms in G Protein Coupled Receptors takes a look at the way GPCRs are examined today, how they react, how their mutations lead to disease, and the many ways in which they can be screened for compounds that modulate them.
We believe this technology has substantial potential for the discovery of novel drug candidates that target G Protein Coupled Receptors and for evaluating the cross-reactivity of drug candidates across the 'universe' of GPCRs in the human genome.
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