MFN1

(redirected from Fzo homolog)

MFN1

A gene on chromosome 3q26.33 that encodes mitofusin 1, an essential transmembrane GTPase that mediates mitochondrial fusion, an important step in mitochondria morphology which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. It is expressed in the kidney and heart; some isoforms may be overexpressed in tumours, including lung cancer.