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Related to fusin: nuclear fusion, VMware Fusion


A G protein-linked receptor present on certain human cells that is thought to be required for HIV fusion with a target cell.
[fuse, fr. L. fundo, pp. fusum, to melt, + -in]


A gene on chromosome 2q21 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which binds specifically to stromal cell-derived factor-1, transducing a signal by increasing intracellular calcium ions and enhancing MAPK1/MAPK3 activation. It acts as a receptor for extracellular ubiquitin, is involved in haematopoiesis and in cardiac ventricular septum formation, plays a role in gastrointestinal tract vascularisation by regulating vascular branching and/or remodelling in endothelial cells, may be involved in cerebellar development and, in the CNS, may mediate hippocampal-neuron survival.

Molecular pathology
CXCR4 acts with the CD4 to support HIV entry into cells; it is highly expressed in breast cancer cells. CXCR4 mutations cause WHIM (warts, hypogammaglobulinaemia, infections, and myelokathexis) syndrome.


A G protein-linked receptor present on certain human cells that is thought to be required for HIV fusion with a target cell.
[fuse, fr. L. fundo, pp. fusum, to melt, + -in]
References in periodicals archive ?
Tiradito reinterprets kinilaw using raw tuna loin covered with a gel made of coconut milk, calamansi and tabon-tabon, a souring ingredient, which was introduced at Madrid Fusin last year by Segismundo and Fores.
Like last year, the room at Madrid Fusin was filled with Filipino pride perhaps because we saw ourselves in Gonzalez who personifies the Philippine and Spanish connection, a man who appreciates himself the more he learns about his roots.
In similar studies, investigators have now shown that SDF-1 can block the HIV strains that depend on fusin.
Like fusin, CC-CKR-5 is a receptor, a protein that normally binds to extracellular molecules and transmits signals into the cell.
Berger's group reported the discovery of fusin last month.
Our research shows that a second molecule, fusin, is required for certain strains of HIV to fuse with and enter into cells.
Through a process of elimination that involved repeatedly dividing cell cultures to find the most blue cells, the researchers narrowed their search to one protein, fusin.
Teo and ICEX Espaa Exportacin e Inversiones President Jaime Garca-Legaz recently signed a Memorandum of Understanding to stage the third edition of Madrid Fusin Manila.
Other researchers hail the long-awaited identification of this protein, which Berger's group calls fusin, as a major advance in scientists' knowledge of HIV's life cycle.
Nokias next-generation optical solution has been selected by Telefnica Spain for its new metro transport network to handle the massive traffic growth fueled by its successful Fusin quadruple-play services.
Support services for the project HAMIFU hardware migration fusin - Use of a transitional system to replace fusin server based on Ubuntu and VirtualBox EVB-IT by entering into a service agreement for 24 months (2 years).