furanocoumarin


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furanocoumarin

(fyūr-a-nō-kū-mah'rinz),
Member of a group of chemical compounds found in grapefruit, which includes bergamottin and 6'7'-dihydroxybergamottin. Inhibit CYP450 3A4, particularly in the GI tract.
See also: bergamottin.

furanocoumarin

naturally occurring photodynamic substances in plants and probably fungi. See also furocoumarin.
References in periodicals archive ?
Effect of maturity, processing, and storage on the furanocoumarin composition of grapefruit and grapefruit juice.
37] Vimal V, Devaki T Linear furanocoumarin protects rat myocardium against lipidperoxidation and membrane damage during experimental myocardial injury.
Leaves and stalks of celery contain phenols, furanocoumarin, psoralen, bergapten, fully and xanthotoxin that their amount is changing from 12 to 50 mg/kg [13].
Guo LQ, Fukuda K, Ohta T, Yamazoe Y: Role of furanocoumarin derivatives on grapefruit j uice-mediated inhibition of human CYP3A activity.
In vitro metabolism of a linear furanocoumarin (8-methoxypsoralen, xantho-toxin) by mixed-function oxidases of larvae of black swallowtail butterfly and fall arrnyworm.
PAL is also known to be involved in the lignification process and as a key enzyme in phenylpropanoid biosynthetic pathway, which is the gateway to many plant secondary metabolites such as flavonoids pigments, furanocoumarin, isoflavonoid, phytoalexin, wound protectant hydroxycinnamic acid esters and aromatic compound in the plant defense system (Dixon et al.
Grapefruit contains the flavonoids, naringenin and furanocoumarin bergamottin--inhibitors of intestinal CYP3A4.
AFG2), are furanocoumarin derivatives and potent liver carcinogens for
Since then, several natural compounds in grapefruit have been identified that are involved in the food-drug interaction, including the flavonoid naringin and the psoralen furanocoumarin.
Role of furanocoumarin derivatives on grapefruit-mediated inhibition of human CYP3A4 activity.
furanocoumarin induction in wild parsnip; Zangerl and Berenbaum 1995), others have been reported to occur range of spatial scales, from WP to single-leaf responses (e.
Thus, an evolutionary increase in production of any specific furanocoumarin would be constrained by selection for increased production of others.