adiposogenital dystrophy (redirected from Froelich's syndrome)

dystrophy /dys·tro·phy/ (dis´trof-e) any disorder due to defective or faulty nutrition.dystroph´ic

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adiposogenital dystrophy  a condition marked by adiposity of the feminine type, genital hypoplasia, changes in secondary sex characters, and metabolic disturbances; seen with lesions of the hypothalamus.

Becker's muscular dystrophy , Becker type muscular dystrophy a form closely resembling pseudohypertrophic muscular dystrophy but having a late onset and slowly progressive course; transmitted as an X-linked recessive trait.

Duchenne's dystrophy , Duchenne's muscular dystrophy, Duchenne type muscular dystrophy the most common and severe type of pseudohypertrophic muscular dystrophy; it begins in early childhood, is chronic and progressive, and is characterized by increasing weakness in the pelvic and shoulder girdles, pseudohypertrophy of muscles followed by atrophy, lordosis, and a peculiar swinging gait with the legs kept wide apart.

Emery-Dreifuss muscular dystrophy  a rare X-linked form of muscular dystrophy beginning early in life and involving slowly progressive weakness of the upper arm and pelvic girdle muscles, with cardiomyopathy and flexion contractures of the elbows; muscles are not hypertrophied.

facioscapulohumeral muscular dystrophy  a relatively benign form of muscular dystrophy, with marked atrophy of the muscles of the face, shoulder girdle, and arm.

Fukuyama type congenital muscular dystrophy  a form of muscular dystrophy with muscle abnormalities resembling those of Duchenne's muscular dystrophy; characterized also by mental retardation with polymicrogyria and other cerebral abnormalities.

Landouzy dystrophy , Landouzy-Dejerine dystrophy, Landouzy-Dejerine muscular dystrophy facioscapulohumeral muscular d.

Leyden-Möbius muscular dystrophy , limb-girdle muscular dystrophy slowly progressive muscular dystrophy, usually beginning in childhood, marked by weakness and wasting in the pelvic girdle (pelvifemoral muscular dystrophy) or shoulder girdle (scapulohumeral muscular dystrophy) .

muscular dystrophy  a group of genetically determined, painless, degenerative myopathies marked by muscular weakness and atrophy without nervous system involvement. The three main types are pseudohypertrophic muscular d., facioscapulohumeral muscular d., and limb-girdle muscular d.

myotonic dystrophy  a rare, slowly progressive, hereditary disease, marked by myotonia followed by muscular atrophy (especially of the face and neck), cataracts, hypogonadism, frontal balding, and cardiac disorders.

oculopharyngeal dystrophy , oculopharyngeal muscular dystrophy a form with onset in adulthood, characterized by weakness of the external ocular and pharyngeal muscles that causes ptosis, ophthalmoplegia, and dysphagia.

pseudohypertrophic muscular dystrophy  a group of muscular dystrophies characterized by enlargement (pseudohypertrophy) of muscles, most commonly Duchenne's muscular d. or Becker's muscular d.

reflex sympathetic dystrophy  a series of changes caused by the sympathetic nervous system, marked by pallor or rubor, pain, sweating, edema, or osteoporosis, following muscle, bone, nerve, or blood vessel trauma.

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ad·i·po·so·gen·i·tal dystrophy (d-ps-jn-tl)

n.

A disorder characterized primarily by obesity and genital hypoplasia either of which may be caused by a tumor of the adenohypophysis or lesions of the hypothalamus.

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adiposogenital dystrophy

[ad′ipō′sōjen′itəl]

Etymology: L, adeps + genitalis, generation

a disorder occurring in males, characterized by genital hypoplasia and feminine secondary sex characteristics, including female distribution of fat. It is caused by hypothalamic malfunction or by a tumor in the adenohypophysis. Hypothermia, hypotension, and hypoglycemia are frequently associated with the disorder. Diabetes insipidus also results from hyposecretion of antidiuretic hormone, which causes increased output of diluted urine, electrolyte imbalances, and thirst. In addition, involvement of the satiety center may induce overeating and result in pronounced obesity. If a tumor is present, there may be drowsiness and symptoms of increased intracranial pressure (for example, subtle locus of control changes and headache). Treatment may include the administration of testosterone and a weight-reduction program, excision or radiologic ablation of a tumor, and replacement of hormones, as necessary. Also called adiposogenital syndrome, Fröhlich's syndrome.

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adiposogenital dystrophy, adiposogenital syndrome

a disease characterized by abnormal distribution of fat (obesity) accompanied by underdevelopment of the genitalia. The condition is caused by damage to certain parts of the hypothalamus, with a decrease in the secretion of gonadotropic hormones from the anterior lobe of the pituitary gland. Treatment depends on the primary cause of the condition, usually a tumor or infection involving the hypothalamus. Called also Fröhlich's syndrome.