Freund's adjuvant


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Related to Freund's adjuvant: Freund's incomplete adjuvant

Freund's adjuvant

(froindz)
n.
A substance consisting of killed microorganisms, such as mycobacteria, in an oil and water emulsion that is administered to induce and enhance the formation of antibodies.

Freund's adjuvant

An emulsion of killed bacteria in oil that induces antibody formation. (Jules Thomas Freund, 1890–1960, Hungarian-born American bacteriologist).
References in periodicals archive ?
1996) where they used Montanide ISA 50 oil adjuvant was shown to be similarly effective to the Freund's adjuvant preparation on laboratory challenge of immunised goats and sheep.
Protective anti-Helicobacter immunity is induced with aluminum hydroxide or complete Freund's adjuvant by systemic immunization.
Five animal groups each consisted of seven pathogen-free, female BALB/c mice (6-8 weeks of age-average 20 g of weight) were handled according to the international animal care ethics and immunized with HBsAg, HBsAg-containing archaeosomes (HBsAg+ Arch), HBsAg-free archaeosomes (Arch) and HBsAg with complete/incomplete Freund's adjuvant (HBsAg+C/IFA).
In this study, we produced VLP of a regional variant HPV16 L1, and then immunized three groups of BALB/c mice with VLP (L1N), VLP with Freund's adjuvant (L1A) or VLP with recombinant IL-12 plasmid (L1P), respectively.
SM (100 [micro]g/ml) with GA (500 [micro]g/ml) dissolved in sterile DPBS was mixed with Incomplete Freund's Adjuvant (IFA) [SM/GA/IFA] at a 1:1 ratio by volume.
The bands were dried and homogenized in complete Freund's adjuvant for the first dose and in incomplete adjuvant for the subsequent three weekly doses.
Female BALB/c mice (7-8 weeks of age) were immunized by subcutaneous injection of 30 [micro]g of bovine S100B emulsified in complete Freund's adjuvant.
The Company postulates that an immune-based therapy containing TCR peptides with Incomplete Freund's Adjuvant (IFA) stimulates regulatory T-cells capable of suppressing these autoreactive pathogenic T-cells.
Mice were immunized three times with an emulsion type II collagen in incomplete Freund's adjuvant (Sigma-Aldrich) until they developed CIA.
After oral administration, CAN (3, 9, and 27 mg/kg) reduced the development of carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats.
The Company postulates that a vaccine containing TCR peptides with Incomplete Freund's Adjuvant (IFA) stimulates regulatory T-cells capable of suppressing these autoreactive pathogenic T-cells.