free radical theory

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free radical theory

A theory which posits that the changes seen in ageing cells and organisms are due to an accumulation of molecules damaged by free radicals. The host cell’s defences against free radical damage include glutathione peroxidase, alpha-tocopherol (vitamin E) and superoxide dismutase; intracellular superoxide levels are believed to correlate well with lifespan.
References in periodicals archive ?
Wikipedia explains that "a high antioxidant capacity is believed to play an important role in the free-radical theory of aging.
Among the numerous hypotheses developed to understand the aging process, the free-radical theory of aging has become especially prominent (Harman, 1956).
Thus far, the free-radical theory hasthe widest acceptance.
The free-radical theory of aging is based on the hypothesis that the endogenous build-up of free-radical species results in oxidative molecular damage.