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Digoxin has a positive inotropic effect, shifts the Frank-Starling curve upward and leftward, and results in greater stroke volume generation for a given myocardial contraction, [2] achieved through altered balance in the handling of intracellular [Na.
In normal physiological conditions, both ventricles operate on the ascending portion of the Frank-Starling curve and cardiac function is regarded as being 'preload dependent (9).
In addition, both ventricles must operate on the ascending portion of the Frank-Starling curve (biventricular preload dependence) (9).