dysostosis (redirected from Franceschetti syndrome)

dysostosis /dys·os·to·sis/ (dis″os-to´sis) defective ossification; defect in the normal ossification of fetal cartilages.

---

cleidocranial dysostosis  a hereditary condition marked by defective ossification of the cranial bones, absence of the clavicles, and dental and vertebral anomalies.

craniofacial dysostosis  a hereditary condition marked by acrocephaly, exophthalmos, hypertelorism, strabismus, parrot-beaked nose, and hypoplastic maxilla.

mandibulofacial dysostosis  a hereditary disorder occurring in a complete form (Franceschetti syndrome) and a less severe form (Treacher Collins syndrome), with antimongoloid slant of the palpebral fissures, coloboma of the lower lid, micrognathia and hypoplasia of the zygomatic arches, and microtia.

metaphyseal dysostosis  a skeletal abnormality in which the epiphyses are normal and the metaphyseal tissues are replaced by masses of cartilage, producing interference with enchondral bone formation.

dysostosis mul´tiplex  Hurler's syndrome.

orodigitofacial dysostosis  orofaciodigital syndrome.

---

dys·os·to·sis (dss-tss)

n.

The defective formation of bone. Also called dysosteogenesis.

---

dysostosis

[dis′ostō′sis]

Etymology: Gk, dys + osteon, bone, osis

an abnormal condition characterized by defective ossification, especially defects in the normal ossification of fetal cartilages. Kinds of dysostoses include cleidocranial dysostosis, craniofacial dysostosis, mandibulofacial dysostosis, metaphyseal dysostosis, and Nager's acrofacial dysostosis.

---

dysostosis [dis″os-to´sis]

defective ossification; a defect in the normal ossification of fetal cartilages.

cleidocranial dysostosis an autosomal dominant condition in which there is defective ossification of the cranial bones, complete or partial absence of the clavicles, so that the shoulders may be brought together, or nearly together, in front, and dental and vertebral anomalies. See illustration.

Cleidocranial dysostosis. From Dorland's, 2000.

craniofacial dysostosis an autosomal dominant condition marked by a pointed or conical skull, protruding wide-set eyes, strabismus, parrot-beaked nose, and hypoplastic maxilla with relative mandibular prognathism. Called also Crouzon's disease.

mandibulofacial dysostosis a hereditary disorder occurring in two different forms: the complete form is Franceschetti syndrome and the incomplete form is Treacher Collins syndrome. Persons with the condition have downslanting eyes (antimongoloid palpebral fissures); absence of all or part of the lower lid; underdeveloped cheekbones that appear depressed; a prominent nose, wide mouth, and small receding chin; underdeveloped, malformed, or prominent ears; and small tufts of hair in front of the ears. There is often, but not always, some degree of hearing loss, usually conductive.

metaphyseal dysostosis a skeletal abnormality in which the epiphyses are normal or nearly so, and the metaphyseal tissues are replaced by masses of cartilage, producing interference with endochondral bone formation and expansion and thinning of the metaphyseal cortices.

orodigitofacial dysostosis orofaciodigital syndrome.

---

dysostosis (dis··stōˑ·sis),

n condition marked by defective ossification, particularly the abnormal ossification of fetal cartilages.

---

dysostosis (disostō´sis),

n defective ossification.

dysostosis, cleidocranial

(klī´dōkrā´nēl),
n (Sainton's disease), See dysplasia, cleidocranial.

dysostosis, craniofacial,

n See syndrome, Crouzon.

dysostosis, mandibulofacial (TreacherCollins syndrome),

n a developmental disturbance of the cranial bones and hypoplasias of the upper part of the face. The mandibular body is underdeveloped, but the ramus is hyperplastic. The teeth are crowded and malposed.

dysostosis multiplex,

n See syndrome, Hurler's.

---

dysostosis

defective ossification; a defect in the normal ossification of fetal cartilages.