Framingham Heart Study


Also found in: Acronyms, Wikipedia.

Framingham Heart Study

 
a longitudinal study begun in 1948 in which there is and has been continuous gathering of data on the health and habits of the adult inhabitants of Framingham, Massachusetts. Data from this study have shown relationships between cardiovascular disease and such variables as smoking, diet, lack of exercise, and other facets of a person's lifestyle.

Fram·ing·ham Heart Stud·y

the first major U.S. study of the epidemiology of cardiovascular disease, begun in Framingham, Massachusetts, in 1948 under the auspices of the National Heart Institute (now the National Heart, Lung, and Blood Institute) and still in operation. Initially the Framingham researchers enrolled 5209 men and women between the ages of 30 and 60 to study the evolution of heart disease and identify risk factors for heart attack. In 1971, the Framingham Offspring Study enrolled 5,124 adult children of original study participants along with their spouses, and in 2001 the Third Generation Study recruited some 3,500 grandchildren of original enrollees.

Framingham, about 20 miles west of Boston, was chosen as the site of this long-term epidemiologic study because it was close to major medical centers and had participated in an earlier population-based investigation of tuberculosis. Participants undergo periodic physical examination, electrocardiography, and laboratory testing. The Framingham study has produced more than 1,000 scientific papers and has had a major impact on the modern understanding of cardiovascular disease and the prevention and treatment not only of heart attack but also of stroke. During the 1960s, cigarette smoking, elevated cholesterol, hypertension, obesity, and lack of exercise were all statistically confirmed to be risk factors for heart attack. In succeeding years, the study provided valuable information on triglycerides, LDL cholesterol, mitral valve prolapse, heart failure, atrial fibrillation, stroke, diabetes, cardiovascular risk factors in ethnic minorities, and the role of estrogen in preventing heart attack in postmenopausal women. The current emphasis is on identifying genetic and molecular risk factors for heart disease and other cardiovascular disorders.

Framingham Heart Study

, Framingham Study [named for Framingham, MA, the town where the investigation took place]
A study of the risk factors that contribute to the development of coronary artery disease and stroke, performed with a group of about 5000 residents of a small New England town under the auspices of the National Institutes of Health (National Heart, Lung, and Blood Institute). The study began shortly after World War II and has followed a cohort of individuals, aged 30-62, for signs and symptoms of atherosclerotic vascular disease and those physical findings and lifestyle choices that contribute to the development of the disease. In 1971, 5124 children of the original cohort were enrolled in the study, and in 2002, a third generation of townspeople were enrolled in an attempt to further understand genetic factors that contribute to the development of heart attack and stroke. The Framingham study identified the major acknowledged risk factors for vascular disease: diabetes, high blood pressure, hyperlipidemia, obesity, a sedentary lifestyle, and smoking. The Framingham database has also been used to explore illnesses other than heart disease, including arthritis, dementia, lung disease, osteoporosis, and a wide variety of genetic illnesses.
References in periodicals archive ?
Data source: Prospectively acquired data on 343 maternal-child pairs enrolled in the Framingham Heart Study.
A follow-up study over five years of 1,739 children of the original participants in the Framingham Heart Study showed that those with low blood levels of vitamin D had twice the risk of having a heart attack or stroke than those with higher blood levels of vitamin D.
Due to the nature of the data uniquely available for this study through the Framingham Heart Study, these findings will be difficult to replicate.
Those taking part in the research had been recruited to the Framingham Heart Study, a large scale investigation of heart disease risk factors in more than 5,000 US volunteers.
Scientists in the US studied 3,267 men taking part in a major health investigation called the Framingham Heart Study.
A CHANGE OF HEART: How the Framingham Heart Study Helped unravel the Mysteries of Cardiovascular Disease DANIEL LEVY AND SUSAN BRINK
The Framingham Heart Study (Framingham, MA), for example, was established in 1948 at a time when heart disease and stroke were epidemic in the United States.
The other study, reported in the Annals of Internal Medicine, looked at life expectancy for 40-year-olds enrolled in the Framingham Heart Study.
A study examined the iron intake of older participants in the Framingham Heart Study and looked at their risk for disease.
Just recently, a new study using data from the Framingham Heart Study assessed the lifetime risk by age and gender.
Risk IDentifier processes this data through a rules engine based on national guidelines from the American Heart Association, American Diabetes Association, National Cholesterol Education Program, Adult Treatment Panel III and the Framingham Heart Study.
Data from the Framingham Heart Study 1996-2000 suggest that low vitamin K intake may contribute to lower bone mineral density (BMD) in women.