frameshift mutation

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read·ing-·frame·shift mu·ta·tion

a mutation that results from insertion or deletion of a single nucleotide into, or from, the normal DNA sequence; because the genetic code is read three nucleotides at a time, all nucleotide triplets distal to the mutation will be one step out of phase and misread, and hence translated as different amino acids.

frameshift mutation

(frām′shĭft′)
n.
A mutation in a DNA chain that occurs when the number of nucleotides inserted or deleted is not a multiple of three, so that every codon beyond the point of insertion or deletion is read incorrectly during translation.

frameshift mutation

The deletion or insertion of one or two DNA nucleotides that alters the transcription of each subsequent triplet.
See also: mutation
References in periodicals archive ?
Tumer NE, Parikh BA, Li P, Dinman JD (1998) Pokeweed antiviral protein specifically inhibits Ty 1-directed +1 ribosomal frameshifting and retrotransposition in Saccaromyces cerevisiae.
Furthermore, additional sequence was inserted immediately after the ochre codon to create proximal ochre codons in the two remaining forward reading frames; this served to more promptly terminate translation arising from exonic frameshifting mutations, but this attribute was not necessary for the detection of any of the analytes described in this report.
Hidden genes are often translated via non-canonical mechanisms, such as programmed ribosomal frameshifting, and we are particularly interested in discovering and characterizing new types of non-canonical translation.
NS1' of flaviviruses in the Japanese encephalitis virus serogroup is a product of ribosomal frameshifting and plays a role in viral neuroinvasiveness.