frameshift mutation

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read·ing-·frame·shift mu·ta·tion

a mutation that results from insertion or deletion of a single nucleotide into, or from, the normal DNA sequence; because the genetic code is read three nucleotides at a time, all nucleotide triplets distal to the mutation will be one step out of phase and misread, and hence translated as different amino acids.

frameshift mutation

(frām′shĭft′)
n.
A mutation in a DNA chain that occurs when the number of nucleotides inserted or deleted is not a multiple of three, so that every codon beyond the point of insertion or deletion is read incorrectly during translation.

frameshift mutation

The deletion or insertion of one or two DNA nucleotides that alters the transcription of each subsequent triplet.
See also: mutation
References in periodicals archive ?
Tumer NE, Parikh BA, Li P, Dinman JD (1998) Pokeweed antiviral protein specifically inhibits Ty 1-directed +1 ribosomal frameshifting and retrotransposition in Saccaromyces cerevisiae.
PTC received its first SBIR grant in December of 2000 for the Company's work in Programmed Ribosomal Frameshifting, a unique mechanism utilized by HIV to regulate the production of viral proteins.
These mutations in tumors 9 and 5 were frameshifting mutations in the 5' region of the gene, which would cause a severe truncation of the menin protein.
HIV, however, confronted by limitations of its small genome size, evolved ribosomal frameshifting as a strategy that enables the virus to make two critical proteins, instead of the usual one.
Ribosomal frameshifting is an innovative therapeutic target for HIV," said Stuart Peltz, Ph.